摘要
目的探讨臭氧穴位注射联合脊神经后支射频调节治疗胸背部带状疱疹后遗神经痛(Postherpetic neuralgia,PHN)的临床疗效。方法选取2021年1月—2022年3月期间新疆医科大学第一附属医院疼痛科收治的胸背部PHN患者158例,按随机数字表法分为联合组和对照组,每组各79例。对照组单用脊神经后支射频调节治疗,联合组在对照组基础上加用臭氧穴位注射治疗。治疗8周后和6个月后随访,观察比较两组患者治疗前后疼痛视觉模拟评分(Visual analogue scale,VAS)、匹兹堡睡眠质量指数评分(Pittsburgh sleep quality index,PSQI)、血清肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平、白细胞介素-2(Interleukin-2,IL-2)水平、红外热像温度变化[区域内平均相对温度(Average Skin Temperature,AST)、AST值差值(ΔAST)]、随访期间各类镇痛药物及其他补救措施(神经阻滞、脉冲射频治疗、皮内阻滞等)使用情况及不良反应情况。结果治疗1周、3个月、6个月后两组患者VAS评分均较治疗前明显降低,差异有统计学意义(P<0.05);且联合组治疗后1周、3个月、6个月后VAS评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗1周、3个月、6个月后两组患者PSQI评分均较治疗前明显降低,差异有统计学意义(P<0.05);且联合组治疗1周、3个月、6个月后PSQI评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗1周后两组患者TNF-α水平均较治疗前降低,IL-2水平均较治疗前升高,差异有统计学意义(P<0.05);且联合组治疗1周后TNF-α水平明显低于对照组,IL-2水平明显高于对照组,差异有统计学意义(P<0.05)。治疗1周后两组患者ΔAST值均较治疗前明显降低,差异有统计学意义(P<0.05);且联合组治疗后1周的ΔAST值明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。随访期间,联合组镇痛药物、脉�
Objective To investigate the clinical efficacy of ozone acupoint injection combined with radiofrequency therapy for posterior branch of spinal nerve in the treatment of postherpetic neuralgia(PHN)in the chest and back.Methods A total of 158 patients with PHN in the chest and back who were treated in the Department of Pain Medicine,The First Affiliated Hospital of Xinjiang Medical University from January 2021 to March 2022 were included.They were divided into a combined group(n=79)and a control group(n=79)according to random number table method.The control group was given radiofrequency therapy for posterior branch of spinal nerve alone,while the combined group was treated with ozone acupoint injection on the basis of the control group.Visual analogue scale(VAS),Pittsburgh sleep quality index(PSQI),serum tumor necrosis factor-α(TNF-α)and interleukin-2(IL-2),and changes in infrared thermal image temperature[average skin temperature(AST),AST difference(ΔAST)]before and after treatment,use of various analgesicsand other remedies(nerve block,pulsed radiofrequency therapy,intradermal block,etc.)during follow-up period and adverse reactions were observed and compared between the two groups.Results Compared with the conditions before treatment,the VAS and PSQI scores of the two groups at 1 week,3 months and 6 months after treatment were reduced(both P<0.05),the reductions were more significant in the combined group than the control group(both P<0.05);the TNF-αlevel andΔAST of the two groups were decreased,while the IL-2 level was increased at 1 week after treatment(all P<0.05),and the combined group had more decreases and increase than the control group(all P<0.05).There was no difference in the total incidence of adverse reactions in the two groups during treatment(P>0.05).During follow-up period,the use rates of analgesics and pulsed radiofrequency therapy in the combined group were lower than those in the control group(P<0.05).Conclusion Ozone acupoint injection combined with radiofrequency therapy for posterior
作者
张树丽
王理康
吴蓍妍
张彩琳
ZHANG Shu-li;WANG Li-kang;WU Shi-yan;ZHANG Cai-lin(Department of Pain Medicine,The First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830000;Department of Rehabilitation Medicine,The Third Medical Center of PLA General Hospital,Beijing 100039)
出处
《世界中西医结合杂志》
2023年第2期314-318,323,共6页
World Journal of Integrated Traditional and Western Medicine
基金
新疆维吾尔自治区自然科学基金资助项目(2021D01C326)。
关键词
脊神经后支射频调节治疗
臭氧穴位注射
带状疱疹后遗神经痛
睡眠质量
Radiofrequency therapy for posterior branch of spinal nerve
Ozone acupoint injection
Postherpetic neuralgia
Sleep quality
