摘要
目的研究盐酸倍他司汀治疗椎基底动脉供血不足伴颈动脉斑块的疗效及对患者脑血流动力学的影响。方法选取2021年1月-2022年1月在我院治疗的74例椎基底动脉供血不足伴颈动脉斑块患者为研究对象,采用随机数字表法分为对照组和观察组,各37例。对照组采用常规治疗,观察组在对照组基础上给予盐酸倍他司汀治疗。比较两组临床疗效,椎动脉(VA)、基底动脉(BA)、大脑后动脉(PCA)血流速度,颈动脉内膜中层厚度、颈动脉斑块面积、血流变学指标以及不良反应发生率。结果观察组治疗总有效率为91.89%,高于对照组的81.08%(P<0.05);两组VA、BA、PCA血流速度均高于治疗前,且观察组大于对照组(P<0.05);两组颈动脉内膜中层厚度、颈动脉斑块面积均小于治疗前,且观察组小于对照组(P<0.05);两组血浆黏度、纤维蛋白原均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率为5.41%,与对照组的8.11%比较,差异无统计学意义(P>0.05)。结论盐酸倍他司汀治疗椎基底动脉供血不足伴颈动脉斑块总有效率高,可提高脑血流动力学水平,减小颈动脉斑块面积,降低血流变学指标水平,且不会增加不良反应,具有良好的应用有效性和安全性。
Objective To study the efficacy of betahistine hydrochloride in the treatment of vertebrobasilar insufficiency with carotid plaque and its effect on cerebral hemodynamics.Methods A total of 74 patients with vertebrobasilar insufficiency and carotid plaque treated in our hospital from January 2021 to January 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 37 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with betahistine hydrochloride on the basis of the control group.The therapeutic effect,blood flow velocity of vertebral artery(VA),basilar artery(BA),posterior cerebral artery(PCA),carotid intima-media thickness,carotid plaque area,hemorheology indexes and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.89%,which was higher than 81.08%of the control group(P<0.05).The blood flow velocities of VA,BA and PCA in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).The carotid intima-media thickness and carotid plaque area of the two groups were smaller than those before treatment,and those in the observation group were smaller than those in the control group(P<0.05).The plasma viscosity and fibrinogen of the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 5.41%,which was compared with 8.11%in the control group,and the difference was not statistically significant(P>0.05).Conclusion Betahistine hydrochloride has a high total effective rate in the treatment of vertebrobasilar insufficiency with carotid plaque,which can improve the level of cerebral hemodynamics,reduce the area of carotid plaque,and reduce the level of hemorheological indexes witho
作者
荣艳红
RONG Yan-hong(Department of Neurology,Baodi Clinical College of Tianjin Medical University,Tianjin 301800,China)
出处
《医学信息》
2023年第7期114-116,142,共4页
Journal of Medical Information
关键词
盐酸倍他司汀
椎基底动脉
供血不足
颈动脉斑块
脑血流动力学
Betahistine hydrochloride
Vertebrobasilar artery
Insufficient blood supply
Carotid plaque
Hemodynamics
