摘要
目的:观察麻杏石甘汤合过敏煎加味改善咳嗽变异性哮喘(CVA)患儿临床症状及对其诱导痰炎性因子的影响。方法:将医院2020年1月至2021年1月收治的118例CVA患儿纳为研究对象,采用随机数字表法将其均分为观察组与对照组,其中对照组接受常规西医治疗,观察组在对照组治疗基础上联用麻杏石甘汤合过敏煎加味,随访1个月,比较两组患儿咳嗽及伴随症状积分、痰诱导液炎性因子水平[白细胞介素-10(IL-10)、白细胞介素-5(IL-5)、肿瘤坏死因子-α(TNF-α)、中心粒细胞、嗜酸性粒细胞]、肺功能[用力肺活量(FVC)、第1秒用力呼吸容积(FEV1)、FEV1/FVC]及治疗效果,随访3个月,比较两组CVA患儿哮喘急性发作次数。结果:该研究中未有病例脱落,与本组治疗前比较,两组咳嗽症状及伴随症状得分均明显降低(P<0.05);治疗后与对照组比较,观察组咳嗽症状与伴随症状得分更低(P<0.05),与本组治疗前比较,两组肺功能指标FVC、FEV1及FEV1/FVC均升高(P<0.05);治疗后与对照组比较,观察组肺功能指标FVC、FEV1及FEV1/FVC水平更高(P<0.05)。与本组治疗前比较,两组血清IL-10水平均升高,血清IL-5、TNF-α、中性粒细胞及嗜酸性粒细胞水平均下降(P<0.05);治疗后与对照组比较,观察组血清IL-10水平更高,血清IL-5、TNF-α、中性粒细胞及嗜酸性粒细胞水平更低(P<0.05)。观察组治疗有效率为86.44%(51/59),高于对照组的69.49%(41/59)(χ^(2)=4.933,P<0.05)。两组治疗期间均未出现严重药物不良反应。观察组治疗3个月内急性复发次数为(1.09±0.18)次,低于对照组的(2.83±049)次(P<0.05)。结论:常规西医治疗基础上加服麻杏石甘汤合过敏煎加味汤能有效减轻CVA患儿气道炎症反应,控制患儿咳嗽症状,改善其肺功能,提高治疗效果,减少疾病急性复发频率,且治疗安全性高。
Objective:To investigate effect of Maxing Shigantang and supplemented Guominjian decoction on symptoms and levels of inflammatory cytokines in induced sputum of children with cough variant asthma(CVA).Method:A total of 118 CVA children who were treated in our hospital from January 2020 to January 2021 were enrolled and randomized into the control group and the observation group with the random number table method.Control group received routine western medicine and the observation group was treated by routine western medicine,Maxing Shigantang,and supplemented Guominjian decoction.In the one-month follow-up,the scores of cough and accompanying symptoms,levels of inflammatory cytokines[interleukin-10(IL-10),interleukin-5(IL-5),tumor necrosis factor-α(TNF-α),neutrophil,eosinophil]in induced sputum,pulmonary function parameters[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],and treatment outcomes were compared between the two groups.Moreover,the frequency of acute asthma attacks during the three-month follow-up was also compared.Result:No cases dropped out from this study.After treatment,the scores of cough and accompanying symptoms were decreased in both groups(P<0.05)and were lower in observation group than in control group(P<0.05).After treatment,FVC,FEV1,and FEV1/FVC were raised in both groups and were higher in observation group than in control group(P<0.05).The increase in the level of IL-10 along with the decrease in levels of IL-5,TNF-α,neutrophil,and eosinophil in induced sputum was found in both groups after treatment(P<0.05),and observation group had higher level of IL-10 and lower levels of IL-5,TNF-α,neutrophil,and eosinophil than the control group(P<0.05).The effective rate was 86.44%(51/59)in observation group,which was higher than the 69.49%(41/59)in control group(χ^(2)=4.933,P<0.05).No serious adverse reaction occurred in either group.The frequency of acute asthma attacks during the three-month follow-up was(1.09±0.18)in observation group,which was lower than
作者
仇志锴
王春莲
尤士军
梁雪
庄玲伶
李月
余珊男
QIU Zhikai;WANG Chunlian;YOU Shijun;LIANG Xue;ZHUANG Lingling;LI Yue;YU Shannan(Jilin Academy of Traditional Chinese Medicine,Changchun 130021,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第8期214-219,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
吉林省科技发展计划项目(20191102025YY)。
关键词
麻杏石甘汤
过敏煎加味
哮喘变异性哮喘
儿童
诱导痰炎性因子
Maxing Shigantang
supplemented Guominjian decoction
cough variant asthma
children
inflammatory cytokine in induced sputum
