摘要
动脉粥样硬化是动脉硬化中典型的病变之一,其特征为早期受累血管自内膜开始,先后堆积丰富的黄色粥样脂质,逐渐形成病灶。针对早期动脉粥样硬化的病机辨治特点,提出“脉损”学说,即以病位论治为起始,“浊逆则损脉,营卫不调则脉道自损”二者互为因果的核心观点。从早期动脉粥样硬化的分子机制和发病机制延伸出内皮细胞机械调节血流剪切应力通量与“脉损”学说的相关性。依据“浊逆则损脉,营卫不调则脉道自损”的核心观点,提出了以“复脉扶正”为大法,“从其气则愈”为原则的防治措施。强调脉道自损,治疗仍需疗脉为本。旨在修复动脉粥样硬化早期临床症状难以察觉的缺陷,提高中医药对动脉粥样硬化防治的准确性。
Atherosclerosis(AS)is one of the typical diseases in arteriosclerosis and is characterized by the accumulation of rich yellow atheromatous lipids in the affected vessels starting from the intima and gradually forming lesions.Considering the pathogenesis differentiation and treatment of early AS,we propose the theory of“Channel Injury”,which starts with treatment of the main location.This core of this theory is the mutual causality of“turbidity reversal will damage the pulse pathway,and the disharmony between nutrient qi and defensive qi will damage the pulse pathway”.The correlation between the mechanical regulation of hemodynamic shear stress by endothelial cells and the theory of“Channel Injury”are extended from the medical molecular mechanism and pathogenesis of early AS.Based on the core view that“turbidity reversal with damage the pulse pathway,and the disharmony between nutrient qi and defensive qi will damage the pulse pathway”,the prevention and treatment measures are based on the method of“restoring the pulse and helping the righteousness”and the principle of“healing from its qi”.As the pulse pathway is self-damaging,the treatment still needs to heal the pulse as the basis.The aim is to detect clinical symptoms in the early stage of AS,and improve the accuracy of Chinese medicine in its prevention and treatment.
作者
王雨涵
刘福明
WANG Yuhan;LIU Fuming(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2023年第2期186-190,共5页
Journal of Beijing University of Traditional Chinese Medicine
基金
江苏省重点研发计划项目(No.BE2020683)
江苏省“六大人才高峰”创新人才团队项目(No.TD-SWYY-069)
江苏省中医药科技发展计划重点项目(No.ZD201906)
江苏省中医院创新发展基金项目(No.Y2019CX20)。
关键词
脉损
动脉粥样硬化
血流剪切应力
复脉从气
Channel Injury
atherosclerosis
hemodynamic shear stress
recovering the channel and healing qi
