摘要
目的研究益生菌联合奥美拉唑对小儿急性肠胃炎患儿的综合效果及对CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平的影响。方法选择2019年2月至2021年2月收治的急性肠胃炎患儿82例。采用随机双盲对照法分成两药联合组及常规组,每组41例。常规组予以奥美拉唑治疗,两药联合组则予以益生菌联合奥美拉唑治疗。分析2组临床治疗疗效,临床症状缓解时间,治疗前后CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平变化情况,不良反应发生情况等方面的差异。结果在临床治疗总有效率两药联合组高于常规组(P<0.05)。两药联合组腹痛、腹泻、发热以及呕吐症状缓解时间分别为(3.95±1.02)d、(4.08±1.04)d、(2.08±0.36)d、(3.02±0.87)d,均短于常规组的(7.24±2.12)d、(8.31±2.16)d、(6.25±1.25)d、(7.56±1.34)d(均P<0.05)。治疗后两药联合组CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)水平分别为(69.78±5.12)%、(45.30±4.51)%、(1.58±0.34),均高于常规组的(62.43±4.67)%、(38.62±4.26)%、(1.17±0.30),而CD_(8)^(+)水平为(27.45±2.15)%,低于常规组的(33.47±2.26)%(均P<0.05)。2组嗜睡、皮疹以及高热发生率对比差异无统计学意义(均P>0.05)。结论益生菌联合奥美拉唑对小儿急性肠胃炎患儿的综合效果显著,可缩短腹痛、腹泻、发热以及呕吐症状缓解时间。同时可改善CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平,且不会增加不良反应的发生,值得临床推广应用。
Objective To study the comprehensive effect of probiotics combined with omeprazole on the levels of CD_(3)^(+),CD_(4)^(+)and CD_(8)^(+)in children with acute gastroenteritis.Methods A total of 82 children with acute gastroenteritis admitted to our hospital from February 2019 to February 2021 were enrolled.The patients were randomized 1∶1 to receive omeprazole(conventional group)or probiotics+omeprazole(combination group).The curative effect,symptom remission time,pre-post-treatment CD_(3)^(+),CD_(4)^(+),CD+8 levels,and adverse reactions were included as comparisons.Results The total effective rate was significantly higher in combination group than that in conventional group(P<0.05).The relief time of abdominal pain,diarrhea,fever and vomiting in combination group were(3.95±1.02)d,(4.08±1.04)d,(2.08±0.36)d,(3.02±0.87)d,respectively,which were shorter than those in conventional group(7.24±2.12)d,(8.31±2.16)d,(6.25±1.25)d,(7.56±1.34)d,(all P<0.05).After treatment,the levels of CD_(3)^(+),CD_(4)^(+)and CD 4+/CD_(8)^(+)in combination group were(69.78±5.12)%,(45.30±4.51)%and(1.58±0.34)respectively,which were higher than those in conventional group(62.43±4.67)%,(38.62±4.26)%and(1.17±0.30)%.The level of CD_(8)^(+)in combination group was(27.45±2.15%),which was significantly lower than that in conventional group(33.47±2.26)%,(P<0.05).There was no significant difference in the incidence of lethargy,rash and high fever between groups(all P>0.05).Conclusion For children with acute gastroenteritis,probiotics combined with omeprazole has a significant comprehensive effect,which can shorten the relief time of abdominal pain,diarrhea,fever and vomiting.Thereby,it can improve the levels of CD_(3)^(+),CD_(4)^(+)and CD_(8)^(+)without increasing the adverse reactions,worthy of clinical promotion.
作者
胡淑娟
HU Shujuan(The Eighth Hospital of Wuhan,Hubei,Wuhan 430000,China)
出处
《河北医药》
CAS
2023年第4期555-557,561,共4页
Hebei Medical Journal
关键词
小儿急性肠胃炎
益生菌
奥美拉唑
T淋巴细胞亚群
不良反应
children with acute gastroenteritis
probiotics
omeprazole
T lymphocyte subsets
adverse reactions
