摘要
近些年来,2型糖尿病(T2DM)的患病率逐年上升,2019年全球约有4.17亿名T2DM患者,其中我国T2DM患者高达约1.04亿,这俨然成为严重威胁人类健康和生活品质的重大问题。T2DM主要表现为胰岛素抵抗(IR),即机体不能对胰岛素产生正常反应的状态。而高脂膳食(HFD)的过量摄入是造成IR的主要诱因。越来越多的研究证明,HFD会导致肠道微生态失衡,进而诱发机体代谢组织产生IR。肠道微生态主要是通过调控机体能量代谢和炎症来调控机体糖脂代谢。随着研究的深入,研究者近期发现,由肠道微生态失衡引起的胆汁酸代谢紊乱,也是导致机体产生胰岛素抵抗的又一重要因素。本文从高脂膳食与胰岛素抵抗、肠道菌群与胰岛素抵抗、"肠道菌群-胆汁酸-胰岛素抵抗"轴等几个方面综述高脂膳食、肠道菌群与胰岛素抵抗之间的相互作用。虽然目前尚无研究证实"高脂膳食-肠道菌群-胆汁酸"在胰岛素抵抗的发生和发展中的因果关系,但是肠道菌群与胆汁酸代谢之间的互相调控关系为胰岛素抵抗及T2DM的防治提供了新思路。
In recent years,the incidence rate of Type 2 diabetes mellitus(T2DM)has been increasing.In 2019,there were about 417 million T2DM patients worldwide and 104 million in China,which has been a threat to human health and quality of life.The main symptom of T2DM is insulin resistance(IR)that the body cannot respond normally to insulin.Excessive intake of high fat diet(HFD)is the major incentive of IR.Many studies have proved that HFD can lead to intestinal micro-ecological imbalance,which in turn induces the IR of metabolic tissues.Researches have shown that the intestinal micro-ecology mainly controls the body's glucose and lipid metabolism by regulating the body's energy metabolism and inflammation.Further research suggests that bile acid metabolism disorder caused by intestinal micro-ecological imbalance is also another important cause of insulin resistance in the body.Therefore,this article will review the interactions among high-fat diet,intestinal flora and insulin resistance from different aspects,such as high-fat diet and insulin resistance,intestinal flora and insulin resistance,and the‘gut microbiota-bile acid-insulin resistance’.Although there is no evidence to confirm the causal relationship of‘high-fat diet-intestinal flora-bile acid’in the occurrence and development of insulin resistance,but the mutual regulations between intestinal flora and bile acid metabolism provide enlightenment for insulin resistance,prevention and treatment of T2DM.
作者
钟浩
王俭
冯凤琴
关荣发
杨梦雨
Zhong Hao;Wang Jian;Feng Fengqin;Guan Rongfa;Yang Mengyu(College of Food Science and Engineering,Zhejiang University of Technology,Hangzhou 310014;College of Biosystems Engineering and Food Science,Zhejiang University,Hangzhou 310058)
出处
《中国食品学报》
EI
CAS
CSCD
北大核心
2023年第3期347-364,共18页
Journal of Chinese Institute Of Food Science and Technology
基金
浙江省自然科学基金项目(LQ23C200011)
中国博士后科学基金面上资助项目(2022M721715)。
关键词
高脂膳食
肠道菌群
胆汁酸代谢
胰岛素抵抗
2型糖尿病
high-fat diet
gut microbiota
bile acid metabolism
insulin resistance
Type 2 diabetes mellitus
