摘要
女性重症肌无力(MG)的临床症状与妊娠密切相关,而妊娠及新生儿的结局又与MG的病情控制、合并症及抗体类型相关。肌无力的加重常出现于妊娠早期0~3个月及产后0~3个月。MG母亲易出现的妊娠不良结局主要为胎停和流产,新生儿肌无力和先天性关节弯曲是分娩儿常见的神经肌肉病变。在妊娠期间,MG孕妇的免疫系统受到雌激素/孕激素/泌乳素/糖皮质激素等的调控,主要结果为抑制促炎反应、促进免疫耐受。但MG与妊娠的具体相互关系仍有待进一步的前瞻性队列研究来阐明。
The clinical symptoms of myasthenia gravis(MG)in women are closely related to pregnancy,and the outcome of pregnancy and neonates is related to MG disease control,comorbidities and antibody types.The exacerbation of muscle weakness usually appeared in the first trimester and postpartum 0-3 months.The adverse pregnancy outcomes of MG mothers are mainly fetal arrest and abortion.Neonatal muscle weakness and congenital joint flexion are common neuromuscular lesions in childbirth.During pregnancy,the immune system of MG pregnant women is regulated by estrogen/progesterone/prolactin/glucocorticoid,and the main result is to inhibit pro-inflammatory response and promote immune tolerance.However,the specific interaction between MG and pregnancy remains to be elucidated in prospective cohort studies.
作者
刘晓青
苏曼其其格
罗苏珊
赵重波
张亚丽
Liu Xiaoqing;Su Manqiqige;Luo Sushan;Zhao Chongbo;Zhang Yali(Chifeng Clinical Medical College of Inner Mongolia Medical University,Chifeng 024000,China;Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Neurology,Chifeng Municipal Hospital,Chifeng 024000,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2023年第3期338-343,共6页
Chinese Journal of Neurology
基金
内蒙古自治区研究生科研创新项目 (S20210245Z)。
关键词
重症肌无力
妊娠
重症肌无力
新生儿
下丘脑-垂体-内分泌轴
抗体
Myasthenia gravis
Pregnancy
Myasthenia gravis,neonatal
Hypothalamic-pituitary-endocrine axis
Antibodies
