摘要
目的探讨地衣芽孢杆菌治疗儿童抗生素相关性腹泻的临床疗效及对肠道菌群的影响。方法选取2020年9月至2021年8月安徽省妇幼保健院收治的呼吸道感染合并抗生素相关性腹泻患儿100例,按随机数字表方法将其分为观察组与对照组,每组50例。对照组予常规治疗,在对照组治疗的基础上,观察组另外应用地衣芽孢杆菌口服治疗,每日3次,每次0.25g,5~7天为1个疗程。比较分析两组患儿的临床疗效,以及治疗前、后肠道菌群的变化情况,并观察两组不良反应的发生情况。结果观察组的治疗总有效率(88.00%)明显高于对照组(68.00%),差异有统计学意义(χ^(2)=5.828,P<0.05)。治疗后,两组患儿粪便中乳杆菌和双歧杆菌数量、菌落总数及双歧杆菌/肠杆菌(B/E)比值均较治疗前升高(t=-24.228~-2.156,P<0.05),且观察组均明显高于对照组(t值分别为2.129、2.304、7.014、3.266,P<0.05);而两组患儿粪便中肠球菌和肠杆菌数量、真菌感染率及球/杆菌值均较治疗前下降(观察组t值分别为3.347、5.165、8.660、22.396,P<0.05;对照组中肠杆菌和球/杆菌值的t值分别为2.706、14.200,P<0.05,而肠球菌和真菌感染率差异无统计学意义,P>0.05),且观察组均明显低于对照组(t值分别为-1.539、-2.461、-3.130、-13.301,P<0.05)。两组患儿治疗期间均未见明显不良反应。结论地衣芽孢杆菌治疗儿童抗生素相关性腹泻的临床效果显著,可有效改善肠道菌群失调状态,恢复肠道菌群平衡,且安全性较高。
Objective To investigate the clinical efficacy of bacillus licheniformis in the treatment of children with antibiotic associated diarrhea and its influence on intestinal microflora.Methods From September 2020 to August 2021,100 children with respiratory tract infection combined with antibiotic-related diarrhea admitted to Anhui Province Maternity&Child Health Hospital were divided into the observation group and the control group by random number table method,with 50 cases in each group.The children in the control group were given conventional treatment,and on the basis,the observation group applied with bacillus licheniformis oral treatment additionally,0.25 g once time,3 times a day lasted for 5~7 d.The clinical efficacy of the two groups and the changes of intestinal microflora before and after treatment were compared and analyzed,and the occurrence of adverse reactions in the two groups were observed.Results The total effective rate of the observation group(88.00%)was significantly higher than that in the control group(68.00%),and the difference was statistically significant(χ^(2)=5.828,P<0.05).After treatment,the number of Lactobacillus and Bifidobacterium,total number of colonies and ratio of Bifidobacterium/Enterobacter(B/E value)in feces of both groups were increased compared with before treatment,and the observation group was significantly higher than the control group(t=2.129,2.304,7.014 and 3.266,respectively,P<0.05).However,the number of enterococcus and enterobacter,fungal infection rate and ratio of cocci/bacilli in feces of both groups decreased,and the observation group was significantly lower than the control group(t=-1.539,-2.461,-3.130 and-13.301,respectively,P<0.05).There were no obvious adverse reactions during treatment in the two groups.Conclusion Bacillus licheniformis has a significant clinical effect on antibiotic associated diarrhea in children,which can effectively improve the imbalance of intestinal flora,restore the balance of intestinal microflora,and has a high safety.
作者
蔺小培
何刘媛
柳玉红
李艳
万燕明
LIN Xiaopei;HE Liuyuan;LIU Yuhong;LI Yan;WAN Yanming(Department of Pediatrics,the Affiliated Maternal and Child Health Hospital of Anhui Medical University/Anhui Province Maternity&Child Health Hospital,Anhui Hefei,230001,China)
出处
《中国妇幼健康研究》
2023年第1期49-54,共6页
Chinese Journal of Woman and Child Health Research
基金
安徽省妇幼健康科研课题(2020FY06)。
关键词
儿童
抗生素相关性腹泻
地衣芽孢杆菌
临床疗效
肠道菌群
children
antibiotic associated diarrhea
bacillus licheniformis
clinical efficacy
intestinal microflora
