摘要
目的对磨玻璃结节早期贴壁生长为主型浸润性肺腺癌(lepidic predominant adeno-carcinoma,LPA)和其他病理亚型的CT特征进行分析,并为疾病诊治提供影像学依据。方法选取2020年1月—2021年12月期间江苏省东台市人民医院收治的90例早期浸润性肺腺癌患者为研究对象,均经手术病理确诊,包括纯玻璃结节和实性肿瘤比(consolidation Tumor Ratio,CTR)<1/2的混合结节,分析患者临床特征和病理资料,将这90例患者按照病理亚型分成LPA组(贴壁样生长方式不低于50%)和非LPA组(贴壁样生长方式不足50%),两组分别为48例和42例,对比两组患者肺部磨玻璃结节CT定量特征和定性特征。结果90例患者共有108个结节,其中LPA组为58个,非LPA组结节数目为50个。两组患者结节位置、胸膜凹陷征和空泡征所占比例比较,差异无统计学意义(P>0.05)。LPA组结节直径、CT值、CTR、深分叶征、血管改变、毛刺和支气管改变率分别为(13.72±3.12)mm、(-572.18±102.24)HU、(14.27±1.21)%、56.90%、46.55%、24.14%和60.34%,低于非LPA组,纯磨玻璃结节、瘤肺界面模糊占比高于非LPA组,差异有统计学意义(t=3.205、5.661、35.132,χ^(2)=12.693、16.321、14.304、8.809、7.818、6.039,P<0.05)。结论磨玻璃结节早期LPA与其他病理亚型CT特征各不相同,可通过观察CT特征,准确区分病理类型,为疾病诊治提供影像学依据。
Objective To analyze the CT features of early lepidic predominant adeno-carcinoma(LPA)and other pathological subtypes in early invasive lung adenocarcinoma with ground glass nodules,and to provide imaging basis for disease diagnosis and management.Methods 90 patients with early invasive lung adenocarcinoma admitted to Dongtai People's Hospital of Jiangsu Province from January 2020 to December 2021 were selected as the study sub⁃jects.All were diagnosed by surgical pathology,including mixed nodules with pure glass nodules and Consolidation Tumor Ratio(CTR)<1/2.The patients'clinical characteristics and pathological data were analyzed,and the 90 pa⁃tients were divided into LPA group(no less than 50%of adnexal-like growth pattern)and non-LPA group(less than 50%of adnexal-like growth pattern)according to pathological subtypes,with 48 and 42 cases in the two groups,re⁃spectively.The CT quantitative and qualitative characteristics of pulmonary ground glass nodules were compared be⁃tween the two groups.Results There were 108 nodules in 90 patients,including 58 nodules in the LPA group and 50 nodules in the non-LPA group.There was no statistically significant difference between the two groups when compar⁃ing the proportion of nodule location,pleural indentation and vacuolation sign(P>0.05).nodule diameter,CT value,CTR,deep lobar sign,vascular change,burr and bronchial change rate in the LPA group were(13.72±3.12)mm,(-572.18±102.24)HU,(14.27±1.21)%,and 56.90%,46.55%,24.14%and 60.34%,which were lower than those in the non-LPA group,and the percentage of pure ground glass nodules and tumor-pulmonary interface blurring was higher than those in the non-LPA group,the difference was statistically significant(t=3.205,5.661,35.132;χ^(2)=12.693,16.321,14.304,8.809,7.818,6.039,P<0.05).Conclusion CT features of early LPA and other pathological subtypes of ground-glass nodules are different,the CT features can be observed to accurately distinguish the patho⁃logical types and provide imaging basis for disease diagnosis
作者
陈恩辉
张凯
彭光银
CHEN Enhui;ZHANG Kai;PENG Guangyin(Department of Pathology,Dongtai People's Hospital,Dongtai,Jiangsu Province,224200 China;Department of Im-aging,Dongtai People's Hospital,Dongtai,Jiangsu Province,224200 China)
出处
《系统医学》
2022年第23期45-48,共4页
Systems Medicine
关键词
磨玻璃结节
肺腺癌
电子计算机断层扫描
病理学检查
Ground glass nodules
Lung adenocarcinoma
Electron computed tomography
Pathological examination
