摘要
瘦型非酒精性脂肪性肝病(NAFLD)是指发生在身体质量指数处于正常范围内人群的NAFLD,近年已愈发受到关注。但是由于其病理生理机制尚不明确,瘦型NAFLD的临床管理存在一定困难。本文从遗传因素、代谢紊乱及脂毒性反应3方面总结了瘦型NAFLD的潜在病理生理机制,并梳理了其临床特征、西医诊断和中医辨证要点。提出目前对于瘦型NAFLD患者的管理应使用中西医结合策略,即在西医对症治疗的基础上,引入中医学辨证论治的概念,寻求疾病解决之道。
Lean non-alcoholic fatty liver disease(NAFLD),which occurs in people whose body mass index is within the normal range,has received increasing attention in recent years.Due to its unclear pathophysiological mechanisms,certain difficulties exist in clinical management.This review systematically reviewed relevant domestic and overseas research progress,then summarized the underlying pathophysiological mechanisms of lean non-alcoholic fatty liver disease from genetic factors,metabolic disturbance,and lipotoxicity response.Clinical manifestations,western medicine diagnosis,and traditional Chinese medicine syndrome differentiation regarding lean non-alcoholic fatty liver disease were also sorted out.It is suggested that the management of lean non-alcoholic fatty liver disease should adopt the strategy of Integvc traditional Chinese medicine and western medicine.In other words,on the foundation of symptomatic treatment with Western Medicine,the concept of syndrome differentiation and treatment with traditional Chinese medicine should be introduced to find a solution to the disease.
作者
戴亮
季光
DAI Liang;JI Guang(Institute of Digestive Diseases,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,200032,China)
出处
《中西医结合肝病杂志》
CAS
2023年第3期193-197,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
上海市申康医院发展中心临床医学创新能力三年行动计划项目支持(No.SHDC2020CR4044)。
关键词
瘦型非酒精性脂肪性肝病
病理过程
治疗学
中西医结合
lean non-alcoholic fatty liver disease
painological process
therapeutics
integrated traditional Chinese medicine and western medicine
