摘要
牛呼吸疾病综合征是危害国内外养牛业的一种重要传染病,致病因素包括病毒、细菌以及支原体等病原体和多种应激。养殖一线人员常常只能通过观察牛的呼吸异常而做出初步诊断,对病原体诊断的准确率低。而且,由于该病具有多病因混合感染的特征,实验室诊断也常常针对性不强,导致难以对患病动物的治疗效果及预后做出精准判断。为了给牛呼吸疾病综合征的早期诊断、及时治疗和综合防控提供参考依据,本文就牛呼吸疾病综合征的病原学、流行和危害以及诊断方法进行综述,包括常见病原,临床诊断、分子生物学诊断等常用诊断方法,以及含有急性期蛋白和应激相关激素的宿主生物标志物诊断、转录组学诊断等新型诊断方法,简述其实际应用情况和优缺点,并对未来诊断方法的方向及待解决问题等提出展望。
Bovine respiratory disease complex(BRDC)is one of the most important infectious diseas⁃es that endangers domestic and international cattle industry.The etiological factors include multiple patho⁃gens such as viruses,bacteria,mycoplasmas,as well as various stressors.Clinical diagnosis is preliminarily drawn by observing the abnormal signs such as dyspnea and the accuracy of pathogen diagnosis is low.Fur⁃thermore,because the disease has the characteristics of multi-etiologic mixed infection,the laboratorial diag⁃nosis is often not specific,which makes it difficult to judge the therapeutic effect and prognosis of the dis⁃ease.In order to provide reference for early and accurate diagnosis,timely treatment and effective prevention and control of BRDC,this paper outlined the etiology,epidemiology,hazards,and diagnostic methods of BRDC,including both conventional clinical and molecular biological diagnostics,as well as new methods based on host biomarkers such as acute phase proteins,stress-related hormones,and transcriptomic diagno⁃sis.Further,the practical application,advantages and disadvantages of these methods were briefly described,and the future direction of diagnostic methods and the problems to be solved were also prospected.
作者
闵聪聪
候强强
于凡淞
项志杰
陈颖钰
胡长敏
郭爱珍
MIN Congcong;HOU Qiangqiang;YU Fansong;XIANG Zhijie;CHEN Yingyu;HU Changmin;GUO Aizhen(College of Veterinary Medicine,Huazhong Agricultural University/State Key Laboratory of Agricultural Microbiology/Hubei Hongshan Laboratory,Wuhan 430070,China)
出处
《华中农业大学学报》
CAS
CSCD
北大核心
2023年第2期17-23,共7页
Journal of Huazhong Agricultural University
基金
宁夏回族自治区重点研发计划项目(2021BEF02028)
国家现代农业(肉牛/牦牛)产业技术体系专项(CARS-37)
湖北省重点研发计划项目(2020BBA055)。
关键词
牛呼吸疾病综合征
诊断方法
病原
诊断标志
健康养殖
综合防控
转录组学
bovine respiratory disease complex(BRDC)
diagnostic method
pathogens
diagnostic biomarkers
healthy breeding
comprehensive prevention and control
transcriptome
