摘要
目的 探讨云南省吸毒及合并丙型肝炎病毒(HCV)/人类免疫缺陷病毒(HIV)感染者的血小板计数及特点。方法 收集2020年5月至2021年6月昆明市第三人民医院收治的1 800例云南省吸毒人员为吸毒组,以该院1 809例正常体检人员为对照组,比较两组血小板计数。检测吸毒组中HCV、HIV感染情况,分析吸毒人员血小板减少的性别、年龄特点,以及吸毒合并HCV/HIV感染者的血小板计数。结果 吸毒组血小板计数明显低于对照组,差异有统计学意义(P<0.001);吸毒组血小板计数<100×10^(9)/L的比例明显大于对照组(P<0.001)。吸毒组血小板减少以中度51.61%(160/310)和重度33.23%(103/310)为主,不同血小板减少程度在男、女中的分布差异均有统计学意义(P<0.05)。血小板极重度减少分布在>40~50岁和>50~60岁,中度和重度减少分布在>30~78岁,轻度减少在各个年龄段均有分布。与单纯吸毒组相比,吸毒合并HCV/HIV感染者血小板计数均减少,其中吸毒+HCV感染+HIV感染血小板计数减少最明显,差异均有统计学意义(P<0.05)。结论 云南省吸毒人员血小板计数较健康人低,血小板减少程度以中度和重度为主,极重度减少以中老年人为主。此外,吸毒合并HCV感染及HIV感染可加重血小板减少。
Objective To explore the platelet count and characteristics in the drug users with complicating hepatitis C virus(HCV)/human immunodeficiency virus(HIV) infection in Yunnan Province.Methods A total of 1 800 drug users in Yunnan Province admitted and treated in this hospital from May 2020 to June 2021 were collected as the drug users group,and 1 809 normal subjects with physical examination in this hospital as the control group.The platelet counts were compared between the two groups.The HCV and HIV infections were detected in the drug users group,the sex and age characteristics of thrombocytopenia in the drug users were analyzed,and the platelet counts in the drug users complicating HCV/HIV infection were analyzed.Results The platelet count in the drug users group was significantly lower than that in the control group,and the difference was statistically significant(P<0.001);the proportion of platelet count<100×10^(9)/L in the drug users group was significantly greater than that in the control group(P<0.001).In the drug users group,the thrombocytopenia was mainly moderate(51.61%,160/310) and severe(33.23%,103/310),and the difference in the distribution of different thrombocytopenia degrees between the males and females was statistically significant(P<0.05).Extremely severe thrombocytopenia was distributed in >40-50 years old and >50-60 years old,moderate and severe thrombocytopenia was distributed in> 30-78 years old,and mild thrombocytopenia was distributed in all age groups.Compared with the simple drug users group,the platelet count in the drug users with complicating HCV/HIV infection was decreased,in which the platelet decrease level of drug users+HCV infection+HIV infection was the most significant,and the difference was statistically significant(P<0.05).Conclusion The platelet count in the drug addicts in Yunnan Province is lower than that in the healthy subjects,the degree of thrombocytopenia is mainly moderate and severe,and the extremely decrease is mainly the middle-aged and elderly people.In addition
作者
王晓燕
王霖
马志强
李才信
李晓琴
唐兴蕊
毛红艳
WANG Xiaoyan;WANG Lin;MA Zhiqiang;LI Caixin;LI Xiaoqin;TANG Xingrui;MAO Hongyan(Department of Clinical Laboratory,Kunming Municipal Third People′s Hospital/Yunnan Provincial Clinical Medical Center of Infectious Diseases,Kunming,Yunnan 650301,China)
出处
《检验医学与临床》
CAS
2023年第6期801-804,共4页
Laboratory Medicine and Clinic
基金
云南省教育厅科学研究基金项目资助(2022J0725)
云南省昆明市卫生科技人才培养项目(2022-SW(后备)-70)
云南省昆明市卫生健康委员会卫生科研课题项目(2022-11-01-004)。
