摘要
目的探索抑郁症患者血清中细胞因子水平及其与症状和代谢指标的相关性。方法收集首发或急性复发抑郁症患者108例作为病例组,同时招募健康对照47例作为对照组,测定两组血清中细胞因子IL-4、IL-6、IL-10、IFN-γ及TNF-α水平;使用相关性分析的方法分析抑郁症患者血清中细胞因子水平与抑郁症状和焦虑症状及代谢相关指标的关系,抑郁症状使用HAMD评估,焦虑症状使用HAMA评估,代谢指标包括BMI、TBC、CRE、BUN、UA、TG、CHOL、LDL、HDL、GLU及HbA1c。结果病例组血清中IL-4、IFN-γ及TNF-α浓度显著低于对照组(P<0.05),IL-6和IL-10浓度显著高于对照组(P<0.05)。相关性分析表明,IFN-γ(r=0.20,P<0.05)和TNF-α(r=0.20,P<0.05)浓度与HAMA总分呈正相关;病例组IL-6浓度与TG(r=0.19,P<0.05)、CHOL(r=0.26,P<0.01)及LDL(r=0.22,P<0.05)呈正相关,IL-10浓度与CHOL呈正相关(r=0.21,P<0.05),TNF-α水平与CRE呈负相关(r=-0.22,P<0.05)。结论抑郁症患者细胞因子水平存在异常,并且与代谢指标存在一定关联。
Objective To explore the correlation between serum cytokine levels and symptoms,metabolic indexes in patients with depression.Methods A total of 108 patients with first episode or acute recurrent depression were enrolled as case group,and 47 healthy controls were recruited as control group.The serum levels of IL-4,IL-6,IL-10,IFN-γand TNF-αin the two groups were determined.Correlation analysis was used to analyze the relationships of serum cytokine levels with clinical symptoms and metabolic indicators.Clinical symptoms included depressive symptoms and anxiety symptoms,which were assessed using HAMD and HAMA,respectively.Metabolic indicators included BMI,total bile acid(TBC),creatinine(CRE),blood urea(BUN),uric acid(UA),triglyceride(TG),cholesterol(CHOL),low density lipoprotein(LDL),high-density lipoprotein(HDL),glucose(GLU)and glycosylated hemoglobin(HbA1c)in patients with depression.Results Compared with control group,the levels of IL-4,IFN-γand TNF-αin case group were significantly decreased(P<0.05),while the levels of IL-6 and IL-10 were significantly increased(P<0.05).Correlation analysis showed that IFN-γ(r=0.20,P<0.05)and TNF-α(r=0.20,P<0.05)were positively correlated with total scores of HAMA,but there was no correlation between cytokines and HAMD scores.IL-6 level was positively correlated with TG(r=0.19,P<0.05),CHOL(r=0.26,P<0.01)and LDL(r=0.22,P<0.05)in case group,and IL-10 level was positively correlated with CHOL(r=0.21,P<0.05).The level of TNF-αwas negatively correlated with CRE(r=-0.22,P<0.05).Conclusion The levels of cytokines in patients with depression are abnormal and correlated with metabolic indexes.
作者
贾敏
马亚伟
张欢
范雅娟
马青艳
高成阁
王崴
马现仓
JIA Min;MA Yawei;ZHANG Huan;FAN Yajuan;MA Qingyan;GAO Chengge;WANG Wei;MA Xiancang(Department of Psychiatry,First Affiliated of Xi’an Jiaotong University,Xi’an 710061,China;Department of Psychiatry,Fifth Hospital of Yulin)
出处
《山西医科大学学报》
CAS
2023年第2期255-259,共5页
Journal of Shanxi Medical University
基金
陕西省重点研发计划-一般项目(2022SF-417)。
关键词
细胞因子
代谢异常
抑郁症
cytokines
metabolic disturbance
depression
