摘要
目的 探究中药复方量效关系这一领域的研究现状、研究热点和未来前沿,为今后的研究提供参考。方法 收集中国知网(CNKI)、万方(Wanfang)、维普(VIP)自建库至2022年9月16日与中药复方量效关系相关的文献,通过Note Express V3.6进行文献数据整合并建立中药复方量效关系数据库,以文献计量学为理论支持,利用Cite Space6.1.R3 Advanced最新版本绘制3D图谱,微软Excel 2016列表,对发文趋势、作者、机构、关键词、爆发词、术语等内容进行可视化分析。结果 最终纳入文献2656篇。年度发文量整体呈波动型上升,并在2010年达到顶峰。共有7606名学者参与了该领域的研究,其中仝小林院士、傅延龄教授发文量与平均被引次数较高,为中药复方量效关系研究领域的核心学者,具有较高影响力。涉及690个机构,北京中医药大学为领头机构。经关键词、术语等综合分析显示,“经方”“药对”“实验研究”“数据挖掘”为研究热点,而“药对”“数据挖掘”“半夏”近几年呈现较高爆发强度,预计成为该领域的前沿。另外,建议以中药配伍“十八反”中功效-剂量-毒性拐点的研究为切入点,拓展该领域的研究。结论 中药复方量效关系的研究逐步走向现代化,建议加强各研究团队间的学术交流,以推动该领域的发展,希望中药复方量效研究走出一条以中医药思路为基础结合现代科技发展,且适合自身的科研之路。
Objective To investigate the current status, research hotspots, and future frontiers in the field of dose-activity relationships of traditional Chinese medicine compound prescriptions(TCMCPs), and to provide references for future research. Methods The literature related to the dose-effect relationship of TCMCPs were collected from China Knowledge Network(CNKI), Wanfang, and VIP since the establishment of the library to September 16, 2022;The literature data was integrated through NoteExpress V3.6 and the database of the dose-effect relationship of TCMCPs was established. Based on the theoretical support of bibliometrics, the latest version of CiteSpace 6.1.R3 Advanced was used to draw 3D map and Microsoft Excel 2016 list, and visual analysis was carried out on the publication trend,authors, institutions, key words, outburst words, terms and other contents. Results A total of 2656 articles were eventually included. The number of annual publications showed a fluctuating increase overall and reached a peak in 2010. A total of 7606 scholars were involved in this field of research, among which Academician Tong Xiao-lin and Professor Fu Yan-ling had a high number of publications and average citations, and were the core scholars in the field of the dose-effect relationship of TCMCPs with high influence. A total of 690 institutions were involved, with the Beijing University of Chinese Medicine as the leading institution. A comprehensive analysis of key words and terms showed that the research hotspots were “Jingfang”, “medicine pairs”, “experimental research” and “data mining”, and “medicine pairs”, “data mining” and “pinellia ternate” showed a high intensity of explosion in recent years and were expected to become the frontier of the field. In addition, it was suggested that the study of the efficacy-dose-toxicity inflection point in the “eighteen inverse” of TCM compatibility should be used as an entry point to expand the research in this field. Conclusion The research on the dose-effect
作者
付进杰
刘馨雅
郝征
宋文杰
傅延龄
FU Jin-jie;LIU Xin-ya;HAO Zheng;SONG Wen-jie;FU Yan-ling(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300192,China;The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Medical Research Center for Acupuncture and Moxibustion,Tianjin 300381,China;School of Traditional Chinese Medicine,Beijing University of Traditional Chinese Medicine,Beijing 100029,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第4期1208-1219,共12页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金项目(82104818)。
关键词
中药复方
量效关系
剂量
可视化分析
数据挖掘
traditional Chinese medicine compound prescriptions
dose-effect relationship
dosage
visual analysis
data mining
