摘要
炎性反应在炎性疾病和多种慢性疾病的发生、发展和预后中起着重要作用,长期失控的炎性反应会导致器官组织功能失调或丧失。临床实践和循证证据提示针灸可有效改善多种炎性疾病和慢性疾病的炎性状态。针灸靶器官相关的穴位,可通过调控穴位微环境启动神经调节。针灸信息在中枢进行整合后,通过神经-内分泌-免疫通路,如胆碱能抗炎通路、迷走神经-肾上腺髓质-多巴胺通路、躯体交感反射和下丘脑-垂体-肾上腺轴等,释放神经递质、激素等并最终作用于免疫细胞,调控单核/巨噬细胞、T细胞亚群的胞内信号通路及极化状态,调控靶器官及机体的免疫稳态。因此,笔者认为针灸抗炎可能是治疗多种疾病的普适性作用途径之一,也是针灸调节阴阳平衡的有力诠释,其作用规律及机制的阐明可更好地实现针灸精准治疗的临床转化。
The inflammatory response plays an important role in the onset,development and prognosis of inflammatory diseases and a variety of chronic diseases.Long-term uncontrolled inflammatory response may lead to dysfunction or loss of organ tissue function.Clinical practice and evidence-based medicine suggest that acupuncture can effectively alleviate the inflammatory status of various inflammatory diseases and chronic diseases.Stimulation of acupoints related to internal organs and target organs can initiate neuromodulation by modulating the microenvironment of acupoints.After integration of acupuncture stimulus information in the central nervous system,neurotransmitters,hormones,etc.are released and ultimately act on immune cells through neuro-endocrine-immune pathways,such as the vagus-mediated cholinergic anti-inflammatory pathway,vagus nerve-adrenal medullary-dopamine pathway,somatic sympathetic nerve pathway,and hypothalamic-pituitary-adrenal axis,etc.Ultimately,the intracellular signaling pathways and polarization balance of monocytes/macrophages and T cell subsets are regulated and the immune homeo-stasis of target organs of the body realizes.Therefore,we proposed that the anti-inflammatory action of acupuncture may be one of the universal therapeutic strategies for multiple diseases,and a powerful interpretation of acupuncture in regulating the balance of yin and yang.The elucidation of its anti-inflammatory action rules and mechanism may better realize the clinical transformation of acupuncture and moxibustion precision treatment.
作者
徐枝芳
公一囡
窦报敏
樊泽至
张悦
XU Zhi-fang;GONG Yi-nan;DOU Bao-min;FAN Ze-zhi;ZHANG Yue(Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Acupuncture-Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《针刺研究》
CAS
CSCD
北大核心
2023年第2期111-117,共7页
Acupuncture Research
基金
天津市教委科研计划项目(No.2021KJ121)。
关键词
针灸
慢性疾病
炎性疾病
抗炎
自主神经
临床转化
Acupuncture
Chronic diseases
Inflammatory diseases
Anti-inflammation
Autonomic nerve
Clinical transformation
