摘要
对于采用连续振荡挡板式结晶器进行β型L-谷氨酸的冷却结晶,提出一种基于实验设计的晶体产品尺寸分布预测模型和过程操作条件优化方法。将连续管式结晶器的振荡频率、2个区段的降温速率作为操作变量,设计一个包含3因素3水平的响应面实验方案。通过检测不同实验条件下的晶体产品弦长分布,构建一个基于双层基函数的晶体产品尺寸分布预测模型。然后引入一个关于目标晶体尺寸分布和产品收率的目标函数,并且利用上述预测模型,建立一个优化过程操作条件的方法。通过对β型L-谷氨酸冷却结晶过程的仿真和实验,验证了该方法的有效性和优点。
For using the continuous oscillatory baffled crystallizer(COBC)to conduct cooling crystallization ofβform L-glutamic acid(LGA),a prediction model of product crystal size distribution(CSD)and optimization method of process operation conditions is proposed,based on the design of experiments.The oscillation frequency and cooling rate of two zones of the COBC are taken as the operation conditions to design a 3-factor and 3-level Box-Behnken experimental scheme.By measuring the chord length distribution(CLD)of crystal products under different experimental conditions,a prediction model of the product CSD is constructed based on double-layer basis functions.Then an objective function related to the target CSD and product yield is introduced to establish an optimization method of the process operation conditions,based on the above prediction model.The effectiveness and advantages of the proposed method are verified by simulation and experiments on the cooling crystallization process ofβform LGA.
作者
赵洺延
杨思维
刘涛
于海晨
ZHAO Mingyan;YANG Siwei;LIU Tao;YU Haichen(School of Control Science and Engineering,Dalian University of Technology,Liaoning Dalian 116024,China)
出处
《化学工业与工程》
CAS
CSCD
北大核心
2023年第1期53-59,共7页
Chemical Industry and Engineering
基金
国家自然科学基金面上项目(62173058)
兴辽英才计划项目(XLYC1902030)
教育部重点实验室基金项目(DUT21LAB113)。
关键词
L-谷氨酸冷却结晶
实验设计
晶体尺寸分布
过程优化
连续振荡挡板式结晶器
cooling crystallization of L-glutamic acid
design of experiments
crystal size distribution
process optimization
continuous oscillatory baffled crystallizer
