摘要
目的 探讨联合心肌酶谱、谷氨酰转肽酶(GGT)、联合尿酸(UA)检测对心力衰竭(HF)诊断及预后的意义。方法 选择从2020年1月至2022年1月间河南省职工医院收治的114例HF患者,将97名健康志愿者作为对照组。分析心肌酶谱、GGT、UA检测对HF患者诊断及预后的意义。结果观察组GGT、UA、心肌酶谱[α-HBDH、CK-MB、AST、CK、LDH]各项指标均高于对照组,差异有统计学意义(t=86.843、9.915、71.702、61.280、117.388、74.049、47.226,P<0.05);不同心功能分级患者UA、GGT及心肌酶谱各指标水平(α-HBDH、CK-MB、AST、CK、LDH):Ⅳ级>Ⅲ级>Ⅱ级,差异均有统计学意义(F=6.642、12.176、F=6.419、7.198、20.473、F=7.131、F=6.559,P<0.05);UA+GGT+心肌酶谱联合检测灵敏度(92.11%)及特异度(91.75%)均高于单项检测;预后良好GGT、UA、心肌酶谱(α-HBDH、CK-MB、AST、CK、LDH)各项指标均低于预后不良者,差异有统计学意义(t=13.103、13.531、23.029、27.76、23.95、20.397、47.496,P<0.05)。经多因素分析结果显示:UA、GGT、α-HBDH、CK-MB、AST、CK、LDH指标是影响HF患者预后的危险因素(P<0.05)。结论 UA、GGT、心肌酶谱指标均是影响HF患者预后的相关因素,联合UA、GGT、心肌酶谱检测对HF患者有较高的诊断效能。
Objective To explore the diagnostic and prognostic significance of combined detection of myocardial zymography,glutamyl transpeptidase(GGT) and uric acid(UA) in heart failure(HF).Methods 114 HF patients admitted to Henan Provincial Staff Hospital from January 2020 to January 2022were selected,97 healthy volunteers were selected as the control group.The significance of myocardial enzymes,GGT and UA in the diagnosis and prognosis of HF patients were compared. Results The indicators of GGT(t=86.843),UA(t=9.915)and myocardial zymogram[α-HBDH(t=71.702)、CK-MB(t=61.280)、AST(t=117.388)、CK(t=74.049)、LDH(t=47.226)]in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05). The levels of UA,GGT and myocardial enzymes(α-HBDH,CK-MB,AST,CK,LDH)in patients with different cardiac function grades:grade Ⅳ > grade Ⅲ > grade Ⅱ,the differences were statistically significant(F=6.642,12.176,F=6.419,7.198,20.473,F=7.131,F=6.559,P<0.05). the combined detection sensitivity(92.11%)and specificity(91.75%)of UA + GGT + myocardial enzyme spectrum were higher than those of the single detection. The indicators of GGT,UA,myocardial enzyme spectrum(α-HBDH,CK-MB,AST,CK,LDH)with good prognosis were lower than those with poor prognosis,and the differences were statistically significant(t=13.103,13.531,23.029,27.76,23.95,20.397,47.496,P<0.05). The results of multivariate analysis showed that:UA,GGT,α-HBDH,CK-MB,AST,CK,and LDH indicators were risk factors affecting the prognosis of HF patients(P<0.05). Conclusion UA,GGT and myocardial enzyme spectrum indicators are related factors affecting the prognosis of HF patients,and the combined detection of UA,GGT and myocardial enzyme spectrum has a high diagnostic efficiency for HF patients.
作者
戴恩云
夏源
李长琳
DAI Enyun;XIA Yuan;LI Changlin(Department of Internal Medicine,Henan Staff Hospital,Zhengzhou,Henan,China,450000)
出处
《分子诊断与治疗杂志》
2023年第2期231-234,239,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关计划项目(2018040104)。
关键词
心肌酶谱
GGT
UA
心力衰竭
Myocardial enzyme spectrum
GGT
UA
Heart failure
