摘要
目的基于国家专利数据库,挖掘中药复方专利治疗糖尿病的用药规律。方法在国家知识产权局专利检索及分析平台中检索2016年1月1日-2020年12月31日中医药治疗糖尿病的复方专利,采用古今医案云平台(V2.3.5)进行中药频次统计、性味归经分析、关联规则分析,采用SPSS 25.0软件进行聚类分析和因子分析。结果共纳入有效中药复方专利490个,涉及中药791味,平均每个专利约含中药13~14味;得到高频中药30味,以补益药为首,清热药次之;药性以平、寒、微寒为主,药味以甘、苦、辛居多,归经以肺经、肾经、脾经为主;关联规则分析得到山药-黄芪、生地黄-黄芪等17个药对;聚类分析得到7个药组,因子分析共提取11个公因子。结论中药复方治疗糖尿病以清热润燥、养阴生津为基础,辅以健脾燥湿、祛痰消瘀、泻火解毒,在临床应用时注意痰浊、血瘀、热毒等病理产物,务必厘清病机,标本兼顾。
Objective To analyze the rules of Traditional Chinese Medicine(TCM)for treating diabetes based on the National Patent Database.Methods In the patent search and analysis platform of the China National Intellectual Property Administration,search the invention patents of the TCM compounds for treating diabetes during January 1,2016-December 31,2020.The Ancient and Modern Medical Records Cloud Platform(V2.3.5)was used to conduct the statistics of Chinese materia medica frequency,the nature and meridian entry,and the analysis of association rules.The cluster analysis and factor analysis were carried out with the SPSS 25.0.Results A total of 490 TCM compound patents were included,which involve 791 kinds of Chinese materia medica.For each patent,the number of the Chinese materia medica types was rough 13-14 in average.Remarkably,thirty kinds of Chinese materia medica with high frequencies were obtained,where tonic Chinese materia medica accounted for the largest number,followed by the heat-clearing Chinese materia medica.Among these Chinese materia medica the categories of nature are mainly flat,cold and slightly cold,while the flavors are mostly sweet,bitter and pungent,which mainly belongs to the three meridians of lung,kidney and spleen.As for the results of statistical analysis,the association rule analysis indicated that there were 17 effective kinds of Chinese materia medica pairs,such as Rhizoma Dioscoreae-Astragalus Membranaceus and Radix Rehmanniae Recen-Astragalus Membranaceus.Seven Chinese materia medica groups were derived by the cluster analysis,and 11 common factors were extracted through factor analysis.Conclusions The TCM compounds for treating diabetes are based on clearing heat and moisturizing dryness,nourishing yin and fluid,supplemented by invigorating spleen and removing dampness,dispelling phlegm and dissolving blood stasis,purging fire and detoxification.Notably,in clinical application,phlegm,blood stasis,heat toxin and other pathological products are supposed to be the focus,must identifying the
作者
史佩玉
莫嘉浩
高帅
朱俊霞
倪青
Shi Peiyu;Mo Jiahao;Gao Shuai;Zhu Junxia;Ni Qing(Department of Endocrinology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Spleen and Stomach Diseases,Guangdong Province Traditional Chinese Medical Hospital,Guangzhou 510405,China;Department of Acupuncture,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Endocrinology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)
出处
《国际中医中药杂志》
2023年第2期214-219,共6页
International Journal of Traditional Chinese Medicine
基金
北京市自然科学基金项目(7182143)。
