摘要
帕金森病(Parkinson disease,PD)是中老年常见的神经系统退行性疾病,其临床表现主要包括运动症状和非运动症状。快速眼动睡眠行为障碍是PD患者常见的非运动症状,但目前PD伴睡眠行为障碍的发病机制仍然不清楚。近年来研究发现,多模态MRI可能在PD伴睡眠行为障碍的早期诊断、进展及治疗中发挥着重要作用,本文就各类功能MRI技术在PD快速眼动期睡眠行为障碍中的应用作一综述,评估患者脑结构和功能的改变,为临床治疗确立有效的神经影像学标志物。
Parkinson’s disease(PD)is a common neurodegenerative disease in the middle-aged and elderly.The main clinical manifestations include motor symptoms and non-motor symptoms.Rapid eye movement behavior disorder(RBD)is a common non-motor symptom in PD patients,but the pathogenesis of PD with RBD remains unclear.In recent years,studies have found that multimodal MRI may play an important role in the early diagnosis,progress and treatment of PD with RBD.In this paper,the application of functional magnetic resonance imaging technology in the REM sleep behavior disorder of Parkinson’s disease is reviewed,and the changes in brain structure and function of patients are evaluated in order to establish effective neuroimaging markers for clinical treatment.
作者
王诗雅
魏璇
颜颖
王争
王振常
脱厚珍
WANG Shi-ya;WEI Xuan;YAN Ying(Department of Neurology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《临床和实验医学杂志》
2023年第2期221-224,F0003,共5页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金面上项目(编号:82071257,81871322)
国家自然科学基金青年项目(编号:82202097)
北京友谊医院院启动项目(编号:yyqdkt2019-31)
北京学者项目(编号:[2015]160)
首都医科大学临床专科院(系)培养基金开放课题(编号:CCMU2022ZKYXY010)。
