摘要
目的:探讨太极悬灸联合祛湿强骨汤治疗膝骨性关节炎临床疗效。方法:选择膝骨性关节炎患者86例,根据随机数字表法分为对照组与观察组,各43例,对照组给予祛湿强骨汤治疗,观察组在对照组基础上给予太极悬灸治疗。观察两组治疗前后临床疗效、中医证候评分、WOMAC量表评分以及实验室指标[白细胞介素-1(IL-1)、基质金属蛋白酶-13(MMP-13)、基质金属蛋白酶-3(MMP-3)],超声指标[内侧外缘关节间隙(PJS)、内侧半月板突出值(MRD)]。结果:治疗后观察组总有效率为92.86%高于对照组的76.19%,差异有统计学意义(P<0.05)。治疗后两组中医证候评分、WOMAC量表评分、血清IL-1、MMP-13、MMP-3水平均较治疗前降低,且观察组低于对照组,差异有统计学意义(均P<0.05)。治疗后两组PJS值较治疗前升高,MRD值较治疗前下降,且观察组改变程度大于对照组,差异有统计学意义(均P<0.05)。结论:太极悬灸联合祛湿强骨汤治疗膝骨性关节炎疗效较好,能够有效改善炎症反应和骨关节状态。
Objective:To explore the clinical observation of Taiji moxibustion combined with Qushi Qianggu decoction in treatment of knee osteoarthritis.Methods:86 patients with knee osteoarthritis were selected and divided into control group and observe group,according to random number table method.The clinical efficacy,TCM syndrome scores,WOMAC scale score,laboratory indexes[interleukin-1(IL-1),metalloproteinase-13(MMP-13),matrix metalloproteinase-3(MMP-3)],ultrasound indicators[medial-lateral joint space(PJS),medial meniscus value(MRD)]were observed before and after treatment in the two groups.Results:After treatment,the total effective rate in the observation group was 92.86%higher than that in the control group 76.19%,difference statistically significant(P<0.05).TCM syndrome scores,WOMAC scale score,serum IL-1,MMP-13,MMP-3 levels were lower than pre-treatment,and the observe group were lower than those in the control group,difference statistically significant(all P<0.05).After treatment,PJS values were higher than pre-treatment,and the MRD values lower than pre-treatment,degree of change in the observation group greater than those in the control group,difference statistically significant(all P<0.05).Conclusion:Taiji moxibustion combined with Qushi Qianggu decoction has significant clinical effect in the treatment of knee osteoarthritis.It can effectively improve inflammatory response and bone and joint condition.
作者
余静
尹罗娟
周涵
陈姣凤
张月娟
YU Jing;YIN Luojuan;ZHOU Han;CHEN Jiaofeng;ZHANG Yuejuan(The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410021,China)
出处
《陕西中医》
CAS
2023年第3期370-374,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
湖南省中医药科研计划项目(2020073)。
关键词
膝骨性关节炎
太极悬灸
祛湿强骨汤
中医证候评分
炎症因子
骨关节状态
Knee osteoarthritis
Taiji moxibustion
Qushi Qianggu decoction
TCM syndrome score
Inflammatory factor
Joint condition
