摘要
目的分析银杏达莫注射液用于糖尿病合并脑梗死的效果。方法选择2021年8月至2022年8月洛阳市孟津区送庄镇卫生院收治的80例糖尿病合并脑梗死患者,采用随机数字表法分成对照组(常规治疗)、观察组(在对照组基础上加以银杏达莫注射液)各40例。比较两组疗效;治疗前后日常生活能力量表(ADL)及神经功能缺损量表(NIHSS)得分;治疗前后红细胞比容、血浆黏度、纤维蛋白原及血小板聚集率;治疗前后C-反应蛋白(CRP)、白细胞介素-6(IL-6)及人可溶性细胞间粘附分子1(sIAM-1)水平。结果观察组治疗有效率(97.50%)高出对照组(80.00%),差异有统计学意义(P<0.05)。治疗前,两组ADL及NIHSS得分差异无统计学意义(P>0.05);治疗后,两组ADL得分较前升高,差异有统计学意义(P<0.05),NIHSS得分较前降低,差异有统计学意义(P<0.05),且观察组ADL得分高于对照组,差异有统计学意义(P<0.05),NIHSS得分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组红细胞比容、血浆黏度、纤维蛋白原、血小板聚集率差异无统计学意义(P>0.05);治疗后,观察组红细胞比容、血浆黏度、纤维蛋白原、血小板聚集率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组CRP、IL-6、sIAM-1水平差异无统计学意义(P>0.05);治疗后,观察组CRP、IL-6、sIAM-1水平低于对照组,差异有统计学意义(P<0.05)。结论予以糖尿病合并脑梗死患者银杏达莫注射液效果较为理想,能提升其日常生活能力,减轻其神经功能缺损,改善其血液流变学指标,降低其炎症因子水平,值得临床应用。
Objective To analyze the clinical efficacy of ginkgo leaf extract and dipyridamole injection in the treatment of diabetes mellitus with cerebral infarction.Methods A total of 80 diabetes mellitus patients with cerebral infarction treated from August 2021 to August 2022 in our hospital were selected.According to random number table,patients were divided into control group(N=40,routine treatment)and observation group(N=40,routine treatment,ginkgo leaf extract and dipyridamole injection).Group comparison was performed through the curative effects,activity of daily living(ADL),national institute of health stroke scale(NIHSS)scores,erythrocrit,plasma viscosity,fibrinogen,platelet aggregation rates,Interleukin-6(IL-6),C-reactive protein(CRP)and soluble intercellular adhesion molecule-1(sICAM-1).Results The effective treatment rate in the observation group(97.50%)was higher than control group(80.00%),with significant difference(P<0.05);Before treatment,ADL and NIHSS scores between groups were not significantly different(P>0.05);After treatment,ADL scores for two groups were higher than before,with significant differences(P<0.05);NIHSS scores for two groups were lower than before,with significant differences(P<0.05);ADL scores in the observation group were even higher than control group,with significant differences(P<0.05);NIHSS scores in the observation group were even lower than control group,with significant differences(P<0.05);Before treatment,there were no significant between-group differences about the erythrocrit,plasma viscosity,fibrinogen and platelet aggregation rates(P>0.05);After treatment,the erythrocrit,plasma viscosity,fibrinogen and platelet aggregation rates in the observation group were lower than control group,with significant differences(P<0.05);Before treatment,there were no significant between-group differences about CRP,IL-6 and sICAM-1 levels(P>0.05);After treatment,CRP,IL-6 and sICAM-1 levels in the observation group were lower than control group,with significant differences(P<0.05).Conclusion Th
作者
白亚丽
BAI Yali(Department of Pharmacy,Songzhuang Town Health Center,Mengjin District,Luoyang City Luoyang Henan 471121,China)
出处
《临床研究》
2023年第3期100-103,共4页
Clinical Research
关键词
银杏达莫
糖尿病
脑梗死
日常生活能力
神经功能缺损
血液流变学
ginkgo leaf extract and dipyridamole injection
diabetes mellitus
cerebral infarction
daily living activity
neurological function deficit
hemorheology
