摘要
目的:分析人工肝支持系统治疗后患者细菌感染的病原菌分布情况及耐药性。方法:将2018年1月至2021年12月在江西省上饶市第二人民医院进行人工肝支持系统治疗的150例患者纳入研究,采集标本,通过菌株鉴定与药敏试验,观察病原菌分布情况,计算主要病原菌对不同抗菌药物的耐药性。结果:150例患者中共有82例(54.67%)发生细菌感染,其中腹腔感染发生率最高(P<0.05)。共检出140株病原菌,革兰阴性杆菌占62.14%,对头孢曲松、庆大霉素、哌拉西林、氨苄西林表现出较高的耐药性;革兰阳性球菌占30.72%,对红霉素、庆大霉素、青霉素表现出较高的耐药性。结论:人工肝支持系统治疗后患者发生大肠杆菌、铜绿假单胞菌等革兰阴性杆菌感染的风险最大,对头孢曲松、庆大霉素、氨苄西林等多种抗生素有较高的耐药性。
Objective:To analyze the pathogen distribution and drug resistance of bacterial infection after treatment with artificial liver support system.Methods:150 patients who were treated with artificial liver support system in the Second People’s Hospital of Shangrao City from January 2018 to December 2021 were included in the study.Samples were collected to observe the distribution of pathogens through strain identification and drug sensitivity test,and calculate the resistance of major pathogens to different antibacterial drugs.Results:There were 82 cases(54.67%)of 150 patients with bacterial infection,and the incidence of abdominal infection was the highest(P<0.05);a total of 140 pathogenic bacteria were detected,among which 62.14%were gram-negative bacteria.They showed high resistance to ceftriaxone,gentamicin,piperacillin and ampicillin,30.72%were gram-positive cocci,and showed high resistance to erythromycin,gentamicin and penicillin.Conclusion:The risk of bacterial infection after treatment with artificial liver support system is high.It has high resistance to ceftriaxone,gentamicin,ampicillin and antibiotics.
作者
许东华
XU Donghua(The Second People's Hospital of Shangrao,Shangrao Jiangxi 334099,China)
出处
《药品评价》
CAS
2022年第23期1447-1450,共4页
Drug Evaluation
关键词
肝
人工
肝功能衰竭
细菌感染
病原菌
耐药性
Liver
artificial
Liver failure
Bacterial infection
Pathogen
Drug resistance
