摘要
目的探讨益生菌补充剂对自闭症谱系障碍患儿胃肠道功能和核心症状的影响。方法将200例自闭症谱系障碍患儿按随机抽签法分为研究组(100例)和对照组(100例)。研究组予以益生菌治疗,对照组予以安慰剂治疗,观察6个月。比较两组褪黑素、维生素使用情况及治疗前后行为异常疗效指标(自闭症诊断观察量表、重复行为量表-修订版、社交沟通问卷评分)、生物标记物(白细胞介素-6、瘦素、肿瘤坏死因子-α、纤溶酶原激活物抑制剂-1和粪便钙卫蛋白)水平、适应性行为指标(适应性行为量表-Ⅱ评分)、胃肠道症状疗效指标(胃肠道严重程度指数评分)。结果(1)褪黑素、维生素使用情况:两组褪黑素、维生素补充占比比较差异无统计学意义(P>0.05)。(2)行为异常疗效指标:治疗后两组自闭症诊断观察量表总分、社会影响、受限和重复行为维度评分及重复行为量表-修订版、社交沟通问卷评分均较治疗前显著下降(P<0.01),研究组自闭症诊断观察量表的社会影响维度评分显著低于对照组(P<0.01),两组其他评分比较差异无统计学意义(P>0.05)。(3)生物标记物:治疗后研究组纤溶酶原激活物抑制剂-1水平较治疗前显著升高(P<0.01);治疗后对照组瘦素水平较治疗前显著升高(P<0.05),肿瘤坏死因子-α水平较治疗前显著降低(P<0.05);治疗后两组白细胞介素-6、瘦素、肿瘤坏死因子-α、纤溶酶原激活物抑制剂-1和粪便钙卫蛋白水平比较差异均无统计学意义(P>0.05)。(4)适应性行为指标:治疗后两组适应性行为量表-Ⅱ的的接受技能、家庭技能、应对技能维度评分均较治疗前显著升高(P<0.01),两组比较差异有统计学意义(P<0.01)。(5)胃肠道症状疗效指标:治疗后两组胃肠道严重程度指数的大便气味、胃肠胀气评分均较治疗前显著降低(P<0.01),两组比较差异有统计学意义(P<0.01)。结论益生菌补充剂可明显改
Objective To explore the effects of probiotic supplements on gastrointestinal function and core symptoms in children with autism spectrum disorders(ASD).Methods A total of 200 children with ASD were divided into study group(100 cases)and control group(100 cases)according to the random lottery method.The study group was given probiotic treatment,while the control group was given placebo treatment for 6 months.The use of melatonin and vitamin,the efficacy indicators of abnormal behaviors[autism diagnostic observation schedule,second edition(ADOS-2),repetitive behaviors scale-revised(RBS-R),social communication questionnaire(SCQ)],the level of biomarkers[interleukin-6(IL-6),leptin,tumor necrosis factor-α(TNF-α),plasminogen activator inhibitor 1(PAI-1),fecal calprotectin],the adaptive behavior indicators[adaptive behavior assessment system-second edition(ABAS-Ⅱ)],and the efficacy indicators of gastrointestinal symptoms[6-item gastrointestinal severity index(6-GSI)]before and after treatment were compared between the two groups.Results(1)Use of melatonin and vitamins:There was no significant difference in the proportion of melatonin and vitamin supplement between the two groups(P>0.05).(2)Efficacy indicators of abnormal behaviors:The total score of ADOS-2,the score of social influence,the score of restricted and repetitive behaviors,and the scores of RBS-R and SCQ in the two groups after treatment were significantly decreased compared with those before treatment(P<0.01).The score of social influence of ADOS-2 in the study group was significantly lower than that in the control group(P<0.01),but there was no significant difference in other scores between the two groups(P>0.05).(3)Biomarkers:The level of PAI-1 in the study group after treatment was significantly higher than that before treatment(P<0.01).The level of leptin in the control group after treatment was significantly increased compared with that before treatment(P<0.05),and the level of TNF-αwas significantly decreased compared with that before treatment(P
作者
张丽
王志永
王袆
Zhang Li;Wang Zhiyong;Wang Hui(First author's address Xingyang People's Hospital,Zhengzhou 450000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2023年第1期22-27,共6页
Journal of Clinical Psychosomatic Diseases
