摘要
传统理论认为肿瘤缺乏神经支配,然而越来越多的研究发现肿瘤组织存在神经浸润,且肿瘤和神经系统之间存在复杂的双向交互作用,并与复杂的肿瘤微环境及免疫系统之间联系紧密,深度参与肿瘤的发生发展和转移。本文主要针对肿瘤组织中存在神经浸润,轴突-突触促进肿瘤生长,神经系统调控肿瘤微环境中神经胶质细胞、血管生成和免疫细胞促进肿瘤发生发展,去神经支配抑制肿瘤生长以及肿瘤细胞诱发神经系统的重塑和功能障碍等方面进行综述,以期为神经-肿瘤互作研究及通过靶向调节神经系统治疗肿瘤这一新兴的研究方向提供参考。
Conventional wisdom holds that tumors lack innervation,but a growing body of research confirms the presence of nerves in tumor tissues and a complex two-way interaction between the tumor and the nervous system,which are also closely related to the complex tumor microenvironment and immune system,and deeply involved in the occurrence,development and metastasis of tumors.This paper reviewed the presence of neural infiltration in tumor tissues,the promotion of tumor growth by axon-synapse,the regulation of the tumor microenvironment by the nervous system on the occurrence and development of tumors by glial cells,angiogenesis,and immune cells,the inhibition of tumor growth by denervation,as well as the remodeling and dysfunction of the nervous system induced by tumor cells in order to provide reference for research on neuro-tumor interactions and the targeted regulation of the nervous system in the treatment of tumors.
作者
余明珠
石海莲
吴晓俊
YU Ming-zhu;SHI Hai-lian;WU Xiao-jun(Shanghai Key Laboratory of Compound Chinese Medicines,the Ministry of Education Key Laboratory for Standardization of Chinese Medicines,the SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine,Research Center of Shanghai Traditional Chinese Medicine Standardization,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2022年第12期936-943,共8页
Chinese Journal of Pharmacology and Toxicology
基金
上海市自然科学基金(21ZR1462800)
上海中医药大学研究生创新培养专项(Y2021088)
国家自然科学基金(81603354)
上海高校中药药效物质E研究院项目
上海市复方中药重点实验室开放课题(17DZ2273300)。
关键词
神经系统
肿瘤
突触
肿瘤微环境
肿瘤神经科学
nervous system
tumor
synapses
tumor microenvironment
tumor neuroscience
