摘要
目的 研究大动脉炎患者血清红细胞沉降率(ESR)、白细胞介素6(IL-6)、基质金属蛋白酶-9(MMP-9)水平与超声造影相关参数的关系。方法 纳入2019年1月至2022年4月本院收治的多发性大动脉炎(TA)患者36例(TA组),根据美国国立研究院制定的标准,分为活动组26例,非活动组10例。选取2019年1月-2022年4月本院体检健康者40例为对照组。TA患者均接受超声造影检查。检测并比对各组血清ESR、IL-6及MMP-9水平。采用Pearson法分析血清ESR、IL-6、MMP-9与超声造影参数的相关性。结果 TA组血清ESR、IL-6、MMP-9水平及达峰时间(TTP)高于对照组(P<0.05),峰值强度(PI)、上升支斜率(A)、曲线下面积(AUC)低于对照组(P<0.05)。与非活动组相比,活动组血清ESR、IL-6、MMP-9水平及TTP较高(P<0.05),AUC、A、PI较低(P<0.05)。Pearson法分析显示,ESR、IL-6、MMP-9与AUC、A、PI呈负相关(P<0.05),与TTP呈正相关(P<0.05)。结论 TA患者血清ESR、IL-6、MMP-9水平明显上调,超声造影相关参数与ESR、IL-6、MMP-9有较好的相关性。
Objective To study the relationship between serum erythrocyte sedimentation rate(ESR),interleukin-6(IL-6),matrix metalloproteinase-9(MMP-9) levels and contrast-enhanced ultrasound-related parameters in patients with Takayasu arteritis. Methods 36 patients with Takayasu arteritis(TA)accepted by our hospital from January 2019 to April 2022(TA group) were included. According to the criteria established by the National Institutes of Technology,they were grouped into an active group of 26 cases and an inactive group of 10 cases. A total of 40 healthy subjects from January 2019 to April 2022were selected as control group. All patients with TA underwent contrast-enhanced ultrasonography.The levels of serum ESR and IL-6 and MMP-9 in each group were detected and compared. The correlation between serum ESR,IL-6,MMP-9 and CEUS parameters was analyzed by Pearson method.Results The levels of serum ESR,IL-6,MMP-9,and time to peak(TTP) in TA group were higher than those in control group(P<0.05),the area under the curve(AUC),ascending branch slope(A),peak value Intensity(PI) was lower than those in control group(P<0.05). Compared with the inactive group,the levels of serum ESR,IL-6,MMP-9,and TTP of the active group were higher(P<0.05),and the AUC,A,and PI were lower(P<0.05). Pearson’s method analysis showed that ESR,IL-6,MMP-9 were negatively correlated with AUC,A,and PI(P<0.05),and positively correlated with TTP(P<0.05). Conclusion The levels of serum ESR,IL-6 and MMP-9 in TA patients are significantly up-regulated,and CEUS-related parameters have a good correlation with ESR,IL-6 and MMP-9.
作者
古力斯坦·卡迪尔
娜菲莎·艾力
周敏
穆巴来克·拜合提亚尔
吕娟
Gulistan Kadir;Nafisa Eli;ZHOU Min;Mubarak Baihetyar;LV Juan(Ultrasound Department of Xinjiang Uygur Autonomous Region People's Hospital,Urumqi 830001,Xinjiang,China;The People's Hospital of Xinjiang Uygur Autonomous Region,Undergoing Clinical Examination,Urumqi 830001,Xinjiang,China)
出处
《中国CT和MRI杂志》
2023年第2期79-81,共3页
Chinese Journal of CT and MRI
基金
新疆维吾尔自治区自然科学基金面上项目(2021D01C179)。
