摘要
目的:调查恶性肿瘤住院患者的营养状况,并对其生活质量进行分析。方法:本研究是一项多中心、横断面研究,纳入2014年4月至2019年1月在全国多家三甲医院接受治疗的恶性肿瘤患者为研究对象。应用营养风险筛查2002量表(Nutrition Risk Screening 2002,NRS 2002)与患者主观整体营养状态评估量表(Patient-Generated Subjective Global Assessment,PG-SGA)进行营养风险筛查与评估,利用生物电阻抗技术进行人体成分检测,利用欧洲癌症研究治疗组织生命质量评估问卷(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30-Item Core Instrument,EORTC QLQ-C30)V3.0调查问卷进行生活质量评价。依据PG-SGA评分将患者分为营养良好/可疑营养不良(0~3分)、轻度/中度营养不良(4~8分)与重度营养不良(≥9分)3组,对比分析3组患者的去脂体重、相位角等人体成分指标及躯体功能、疼痛等生活质量各项指标。结果:本研究最终共纳入589例恶性肿瘤患者。营养不良的发生率高达85.91%,而未得到营养干预的比例达80.56%。老年(92.60%)、女性(91.62%)及有合并症的患者(92.01%)营养不良的发生率较高(P<0.05)。随着PG-SGA等级的升高,患者的肌肉质量、四肢骨骼肌质量指数与相位角等人体成分指标呈逐渐降低的趋势(P<0.05)。营养不良患者(PG-SGA评分≥4分)的躯体功能、角色功能等生活质量评价指标较低(P<0.05),而疲倦、疼痛等生活质量评价指标较高(P<0.05)。同时PG-SGA与肌肉质量(r=-0.184,P<0.05)、四肢骨骼肌质量指数(r=-0.208,P<0.05)、相位角(r=-0.390,P<0.05)等人体成分指标及角色功能(r=-0.386,P<0.05)、认知功能(r=-0.326,P<0.05)等生活质量评价指标呈负相关,与恶心呕吐(r=0.675,P<0.05)及食欲丧失(r=0.489,P<0.05)等生活质量评价指标呈正相关。结论:恶性肿瘤住院患者营养不良的发生率较高,而营养干预相对匮乏。肿瘤患者营养不良的发生�
Objective : To investigate the nutrition status of inpatients with malignancies, and analyze their quality of life. Methods : In this multicenter cross-sectional study, malignancy patients who underwent anti-tumor treatments in several level A tertiary hospitals in China from April 2014 to January 2019 were enrolled. Nutrition Risk Screening 2002 and Patient-Generated Subjective Global Assessment(PGSGA) were used to screen and evaluate the nutritional risks of patients. Body composition was detected by bioelectrical impedance analysis. Quality of life of patients was evaluated using the EORTC Quality of Life Questionnaire QLQ-C30(version 3.0). PG-SGA rated the patients as good nutrition/suspected malnutrition(PG-SGA score ≤ 3 points), mild/moderate malnutrition(4 points ≤ PG-SGA score ≤ 8 points) and severe malnutrition(PG-SGA score ≥ 9 points). Body composition indexes such as fat free mass and phase angle, and quality of life indexes including body functions and pain were compared among the three groups. A total of 589 patients with malignancies were finally enrolled in the study. The incidence of malnutrition was up to 85.91%. 80.56% of the patients did not receive nutritional intervention. Results : The elderly(92.60%), females(91.62%) and patients with comorbidities presented higher incidences of malnutrition(P < 0.05). As the PG-SGA rating increases, indicators of body composition such as muscle mass, appendicular skeletal muscle mass index(ASMI) and phase angle showed a gradual decreasing trend(P < 0.05). Patients with malnutrition(PG-SGA ≥ 4 points) reported relatively high physical functioning and role functioning scores(P < 0.05), while relatively low fatigue and pain scores(P < 0.05). Meanwhile, PG-SGA score was negative correlated to muscle mass(r =-0.184, P < 0.05), ASMI(r =-0.208, P < 0.05), phase angle(r =-0.390, P < 0.05), role functioning(r =-0.386, P <0.05) and cognitive functioning(r =-0.326, P < 0.05). It was then positive correlated to nausea/vomiting(r = 0.675, P < 0.05) and appeti
作者
王晓琳
宋春花
李薇
李增宁
黄慧玲
石汉平
Wang Xiaolin;Song Chunhua;Li Wei;Li Zengning;Huang Huiling;Shi Hanping(Department of Clinical Nutrition or Key Laboratory of Cancer FSMP for State Market Regulation,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038,China;Department of Epidemiology,College of Public Health,Zhengzhou University Zhengzhou 450052,Henan,China;CancerCenter,the First Bethune Hospital of Jilin University,Changchun130000,Jilin,China;Department of Nutrition,the First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei,China)
出处
《肿瘤预防与治疗》
2023年第1期8-17,共10页
Journal of Cancer Control And Treatment
基金
国家重点研发计划(编号:2022YFC2009600)。
关键词
恶性肿瘤患者
营养状况
人体成分
相位角
生活质量
Malignancy patients
Nutrition status
Body composition
Phase angle
Quality of life
