摘要
目的采用数据挖掘的方式分析李智杰教授治疗不寐的用方用药规律。方法收集2020年11月—2021年11月就诊的不寐患者150例,提取患者病案中的医药信息,运用Excel软件与IBM SPSS Statistics 28.0软件进行方药频次及分类分析、聚类分析和关联规则分析。结果数据挖掘发现,李智杰教授在150例不寐患者的治疗中共使用了124味药物,药物频次合计2090次。药物频次分析显示,使用频次最高的前10味药为石菖蒲、郁金、黄连、肉桂、远志、茯神、琥珀、沉香、珍珠母、法半夏等,其中前6味为加味菖蒲郁金汤的固定药物组成。药物类别统计分析显示,排名前6的药物类别分别为开窍药、安神药、活血化瘀药、清热药、温里药、理气药。关联规则分析显示,茯神、肉桂、远志三者间关联度最高,且琥珀、远志常作为药对出现,以上四药与沉香关联度也较高。药物聚类分为四类:琥珀、沉香、柏子仁、太子参、远志、茯神安神定志为一类;黄连苦寒为一类;石菖蒲芳香醒神为一类;珍珠母、法半夏、肉桂、郁金温热豁痰为一类。失眠伴随症状可聚为五类:夜间易醒、醒后难入睡、早醒、夜尿、健忘为一类;大便干、醒后疲劳为一类;神疲乏力、多梦为一类;入睡困难、小便黄各为一类。结论李智杰教授对不寐的治疗贴合临床实际与社会实际,在调气机、和阴阳、交心肾之外,着重调节患者的情志。其运用加味菖蒲郁金汤治疗不寐的辨治思路与用药经验颇具特色,值得临床推广。
Objective To analyze the law of perscription and medication of Professor Li Zhijie in treating insomnia by means of data mining.Methods A total of 150 cases of insomnia patients from November 2020 to November 2021 were collected.Medical information in patients’medical records was extracted.The frequency and classification analysis,cluster analysis and association rule analysis of prescriptions and herbs were performed by Excel software and IBM SPSS Statistics 28.0 software.Results Data mining found that Professor Li Zhijie used 124 herbs in 150 patients with insomnia,and the frequency were 2090 times in total.The analysis of frequency showed that the top ten herbs with the highest frequency use were Shichangpu,Yujin,Huanglian,Rougui,Yuanzhi,Fushen,Hupo,Chenxiang,Zhenzhumu,Fabanxia,etc.Among them,the top six were fixed herbs of modified Changpu Yujin decoction.According to the statistical analysis of herbs categories,the top six categories were respectively herbs for resuscitation,herbs for tranquillization,herbs for activating blood and resolving stasis,herbs for heat-clearing,herbs for warming interior,herbs for regulating qi.The analysis of association rules showed that the correlations among Fushen,Rougui,Yuanzhi were the highest,and Hupo and Yuanzhi were often used as couplet medicines.Besides,the above four herbs are also highly associated with Chenxiang.The drug cluster could be divided into four categories:first,Hupo,Chenxiang,Baiziren,Taizishen,Yuanzhi,Fushen(tranquillization and calming mind);second,Huanglian(bitter and cold);third,Shichangpu(aromatic and refreshing);four,Zhenzhumu,Fabanxia,Rougui,Yujin(warm and clearing phlegm).The accompanying symptoms of insomnia could be clustered into five categories:first,easy to wake up at night,difficult to fall asleep,early awakening,nocturia and forgetfulness;second,dry stool and fatigue after waking up;third,fatigue and malaise and dreaminess;at last,difficulty to fall asleep and deep-colored urine(belonging to each category).Conclusion Professor Li Zhijie�
作者
陈灿
李智杰
邓长青
CHEN Can;LI Zhijie;DENG Changqing(Clinical College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430061,China;Department of Encephalopathy,National Medical Hospital Affiliated to Hubei University of Chinese Medicine,Wuhan 430010,China)
出处
《中西医结合研究》
2023年第1期18-23,共6页
Research of Integrated Traditional Chinese and Western Medicine
基金
2018年国家科技部重点研发计划-中医药现代化研究(No.SQ2018YFC175600)。
关键词
李智杰
不寐
加味菖蒲郁金汤
数据挖掘
Li Zhijie
insomnia
modified Changpu Yujin decoction
data mining
