摘要
目的观察丹参归脾汤治疗慢性心力衰竭伴失眠患者的临床疗效。方法选取2020年3月—2021年12月本院脑病科收治的慢性心力衰竭伴失眠患者98例,按照随机数字表法分为治疗组和对照组,每组49例。对照组给予艾司唑仑片,治疗组给予丹参归脾汤,2组患者均连续治疗14 d。比较2组患者治疗前后中医证候积分、血清N末端B型脑钠肽前体(N-terminal B-type brain natriuretic peptide precursor,NT-proBNP)水平、阿森斯失眠量表(Athens insomnia scale,AIS)评分、6分钟步行试验(6 min walking test,6MWT)距离及临床疗效。结果治疗后,治疗组各项中医证候积分、血清NT-proBNP水平、AIS评分均显著低于对照组(P<0.05)。治疗组6MWT距离、临床治疗总有效率显著高于对照组(P<0.05)。结论丹参归脾汤可有效改善慢性心力衰竭伴失眠患者的临床症状,降低NT-proBNP水平,增强心脏功能,改善睡眠质量,提高临床疗效。
Objective To observe the clinical efficacy of Danshen Guipi decoction in treating patients with chronic heart failure with insomnia.Methods Ninety-eight patients with chronic heart failure with insomnia admitted to the department of encephalopathy of our hospital from March 2020 to December 2021,were selected and randomly divided into treatment group and control group,with 49 patients in each group.The control group was treated with estazolam tablets,and the treatment group was treated with Danshen Guipi decoction.Both groups were treated continuously for 14 days.The scores of traditional Chinese medicine syndrome,serum levels of N-terminal B-type brain natriuretic peptide precursor(NT-proBNP),scores of Athens insomnia scale(AIS),6-minute walking test(6MWT)distance,and clinical efficacy of two groups were compared before and after treatment.Results After treatment,scores of traditional Chinese medicine syndrome,serum levels of NT-proBNP,and AIS scores in the treatment group were significantly lower than those in the control group(P<0.05).The distance of 6MWT and total clinical effective rate in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Danshen Guipi decoction could effectively improve the clinical symptoms of patients with chronic heart failure with insomnia,reduce NT-proBNP levels,enhance cardiac function,improve sleep quality,and improve clinical efficacy.
作者
靳晶
刘麒麟
姜磊
刘江华
卢菁
JIN Jing;LIU Qilin;JIANG Lei;LIU Jianghua;LU Jing(Department of Encephalopathy,Wuhan Traditional Chinese Medicine Hospital,Wuhan 430014,China)
出处
《中西医结合研究》
2023年第4期226-229,共4页
Research of Integrated Traditional Chinese and Western Medicine
基金
国家重点研发计划(No.2018YFC1705602)。
