摘要
代谢重编程是细胞为满足能量需求,通过改变代谢模式促进细胞增殖、生长及生物合成的过程,该过程目前已被证实在多种疾病的发生及进展中发挥着重要作用。甲状腺肿瘤为一种常见的内分泌肿瘤,启动代谢重编程促进细胞生长、增殖及侵袭的特征目前成为研究热点。代谢重编程中的一些代谢分子的表达水平与甲状腺肿瘤的预后密切相关。
Metabolic reprogramming is a process in which cells promote cell proliferation,growth and biosynthesis by changing metabolic patterns to meet energy requirements,and this process has been shown to play a crucial role in the occurrence and progression of a variety of diseases.Thyroid tumor is a common endocrine tumor,the characteristic of activating metabolic reprogramming to promote cell growth,proliferation and invasion has become a research hotspot at present.The expression levels of some metabolites involved in metabolic reprogramming are closely related to the prognosis of thyroid tumors.
作者
邹小白
郑旭琴
张永明
Zou Xiaobai;Zheng Xuqin;Zhang Yongming(Department of Endocrinology,Anhui No.2 Provincial People′s Hospital,Hefei 230041,China;Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《国际内分泌代谢杂志》
2022年第6期461-464,共4页
International Journal of Endocrinology and Metabolism
关键词
代谢重编程
糖酵解
甲状腺肿瘤
Metabolic reprogramming
Glycolysis
Thyroid tumor
