摘要
目的 探讨与标准大容量聚乙二醇电解质散(4L PEG-ELS)方案相比,低容量PEG-ELS联合首荟通便胶囊(SHLC)方案对慢性功能性便秘(CFC)患者结肠镜检查前肠道准备的有效性和安全性。方法 采用单中心、观察者盲法、随机对照试验方法,招募2021年1月-2021年12月在山东大学齐鲁医院(青岛)接受结肠镜检查的CFC患者282例,随机分配到SHLC+2 L PEG-ELS组、SHLC+3 L PEG-ELS组和4 L PEG-ELS组。观察患者波士顿肠道准备评分(BBPS)和肠道准备耐受性。结果 最终纳入240例患者。SHLC+2 L PEG-ELS、SHLC+3 L PEG-ELS和4 L PEG-ELS组的BBPS分别为(6.22±1.09)、(6.26±0.97)和(7.06±0.63)分,差异无统计学意义(P> 0.05)。节段性BBPS显示,3组患者在左半结肠[(2.32±0.72)、(2.41±0.64)和(2.58±0.59)分]、中段结肠[(2.18±0.83)、(2.26±0.76)和(2.44±0.81)分]和右半结肠[(1.67±0.71)、(1.72±0.67)和(2.23±0.66)分]方面比较,差异均无统计学意义(P> 0.05)。梅奥耐受性问卷显示4 L PEG-ELS组患者耐受性和再次肠道准备意愿均差于SHLC+3 L PEGELS组和SHLC+2 L PEG-ELS组(P=0.007和P=0.021)。与4 L PEG-ELS组相比,SHLC+2 L PEG-ELS组和SHLC+3 L PEG-ELS组服药后首次排便间隔时间提前(P=0.036),睡前排便次数增加(P=0.035),但在总排便次数方面比较,差异无统计学意义(P> 0.05)。3组患者肠道准备后不良反应发生率无明显差异(P> 0.05)。结论 对于CFC患者的肠道准备,低容量PEG-ELS联合SHLC可能是一种新颖的策略,它提高了患者耐受性和依从性,肠道准备效果和安全性与4 L PEG-ELS标准方案相当。
Objective To investigate the efficacy and safety of a low-volume polyethylene glycol-electrolyte solution(PEG-ELS) in combination with Shouhui Laxative Capsule(SHLC) compared to a standard high-volume regimen(4L PEG-ELS) for bowel preparation before colonoscopy in patients with chronic functional constipation(CFC). Methods This was a single-center, observer-blind, randomized controlled study that recruited 282 patients with CFC who underwent colonoscopy from January 2021 to December 2021 and were randomly assigned to the SHLC + 2 L PEG-ELS group, SHLC+3 L PEG-ELS group and 4 L PEG-ELS group. The primary outcomes were the Boston bowel preparation scale(BBPS) and patient bowel preparation tolerance. Results 240 patients were eventually included. The BBPS scale of SHLC + 2 L PEG-ELS, SHLC + 3 L PEG-ELS, and 4 L PEG-ELS groups were(6.22 ± 1.09),(6.26 ± 0.97), and(7.06 ± 0.63), respectively, and the difference was not statistically significant(P > 0.05). The differences in segmental BBPS among the three groups in the left colon [(2.32 ± 0.72),(2.41 ± 0.64)and(2.58 ± 0.59)], middle colon [(2.18 ± 0.83),(2.26 ± 0.76) and(2.44 ± 0.81)] or right colon [(1.67 ± 0.71),(1.72 ± 0.67) and(2.23 ± 0.66)] were not statistically significant(P > 0.05). The Mayo Tolerance Questionnaire showed that the patient tolerance and willingness to repeat bowel preparation in the 4 L PEG-ELS group were inferior to those in the SHLC + 3 L PEG-ELS group and SHLC+2L PEG-ELS group(P = 0.007 and P = 0.021).Compared with the 4 L PEG-ELS group, the SHLC + 2 L PEG-ELS group and SHLC+3 L PEG-ELS groups had an earlier time between first bowel movements(P = 0.036) and an increased number of bedtime bowel movements(P = 0.035) after taking the drug, but there was no significant difference in the total number of bowel movements(P > 0.05). There was no significant difference in the incidence of adverse events after bowel preparation among the three groups(P > 0.05). Conclusion For bowel preparation in patients with CFC, low-volume PEG-ELS combine
作者
田伟
田震
王一祺
徐振荣
袁妮妮
Wei Tian;Zhen Tian;Yi-qi Wang;Zhen-rong Xu;Ni-ni Yuan(Department of Anorectal Center,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao,Shandong 266000,China;Department of Health Care Endocrinology,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao,Shandong 266000,China)
出处
《中国内镜杂志》
2023年第1期62-70,共9页
China Journal of Endoscopy
关键词
结肠镜检查
聚乙二醇电解质散
首荟通便胶囊
慢性功能性便秘
肠道准备
colonoscopy
polyethylene glycol electrolyte solution
Shouhui Laxative Capsule
chronic functional constipation
bowel preparation
