摘要
目的探究皮敏消胶囊联合糠酸莫米松乳膏治疗湿疹患者的疗效及其对血清中芳香烃受体(AhR)及炎症因子表达的影响。方法采用前瞻性研究方法,选取深圳市中医院2018年1月至2021年1月收治的120例湿疹患者作为研究对象,随机将其分为观察组和对照组,各60例。2组均采取糠酸莫米松乳膏进行治疗,观察组患者在对照组基础上联合采用皮敏消胶囊治疗,均治疗4周,比较2组患者的治疗效果、湿疹面积、严重指数、瘙痒情况、炎症指标、AhR以及并发症之间的差异。结果观察组治疗总有效率(93.33%)高于对照组(80.00%),差异有统计学意义(P<0.05);2组EASI评分、湿疹面积均有所下降,且观察组患者的湿疹面积[(5.25±3.05)vs.(15.26±2.06)分]以及EASI评分[(0.23±0.24)vs.(1.46±0.23)分]低于对照组(P<0.05);2组患者的瘙痒评分均显著下降,且观察组患者的瘙痒评分[(0.25±0.05)vs.(1.26±1.06)分]低于对照组(P<0.05);2组患者的炎症指标以及AhR水平均有所改善,且观察组患者的IL-1β[(42.27±3.31)vs.(52.17±3.27)ng/L]、TNF-α[(18.27±3.72)vs.(20.75±3.73)ng/L]、IL-6[(39.89±5.37)vs.(42.39±5.79)ng/L]、AhR[(4.21±1.25)vs.(5.60±1.26)ng/L]水平(t=6.066,P<0.001)低于对照组。结论湿疹患者采用皮敏消胶囊联合糠酸莫米松乳膏治疗,血清中AhR及炎症因子显著下降,治疗效果较好,建议临床推广。
Objective To study the curative effects of piminxiao capsule combined with mometasone furoate cream on eczema patients and the impacts on the expression of serum AhR and inflammatory factors.Methods Prospective research method was adopted in the study.120 eczema patients admitted for treatment in the hospital from January 2018 to January 2021 were recruited as research subjects,and were randomly divided into the observation and control groups,each consisting of 60 patients.The 2 groups were all treated with mometasone furoate cream,and the observation group further received piminxiao capsules on the basis of the control group,all with a treatment length of 4 weeks.Therapeutic effects,eczema area,severity index,pruritus,inflammatory index,AhR as well as complications were compared between the patients of the 2 groups.Results The total effective rate of observation group was 93.33%,which was significantly higher that(80.00%)of the control group,with statistical significance(P<0.05).The EASI scores and eczema area in the two groups all significantly decreased,with the eczema area and the EASI scores of the observation group being significantly smaller or lower than those of the control group[(5.25±3.05)vs.(15.26±2.06)points]and[(0.23±0.24)vs.(1.46±0.23)points](P<0.05).The pruritus scores in both groups also significantly decreased,with those of observation group being significantly lower than those of the control group[(0.25±0.05)vs.(1.26±1.06)points](P<0.05).The inflammatory indexes and AhR levels in the patients of the 2 groups all significantly improved,with the levels of IL-1β,TNF-α,IL-6and AhR of the former respectively being lower than those of the latter[(42.27±3.31)vs.(52.17±3.27)ng/L],[(18.27±3.72)vs.(20.75±3.73)ng/L],[(39.89±5.37)vs.(42.39±5.79)ng/L],[(18.27±3.72)vs.(20.75±3.73)ng/L]and[(4.21±1.25)vs.(5.60±1.26)ng/L](t=6.066,P<0.001).Conclusion Following treatment with piminxiao capsule and mometasone furoate cream,the serum AhR and inflammatory factor levels in the patients all decreased
作者
王丽娜
赖旻
Wang Lina;Lai Min(Department of Dermatology,Shenzhen Traditional Chinese Medicine Hospital,Guangdong Province,Shenzhen 518033,China)
出处
《海军医学杂志》
2022年第12期1345-1348,共4页
Journal of Navy Medicine
关键词
湿疹
皮敏消胶囊
糠酸莫米松乳膏
炎症反应
AHR
Eczema
Piminxiao capsule
Mometasone furoate cream
Inflammatory reaction
AhR
