摘要
目的:观察序贯外用0.1%糠酸莫米松乳膏与0.03%他克莫司软膏治疗儿童特应性皮炎的疗效、安全性及复发率。方法:收集该院门诊符合入选标准的儿童特应性皮炎患儿270例,随机分为3组。观察组外用0.1%糠酸莫米松乳膏,每晚1次,连续使用2周后,换用0.03%他克莫司软膏,早晚各1次,继续使用2周;对照A组外用0.1%糠酸莫米松乳膏,每晚1次,连续使用4周;对照B组外用0.03%他克莫司软膏,早晚各1次,连续使用4周。治疗结束后观察3组患者临床疗效和不良反应,随访4周,比较复发率。结果:①观察组的湿疹面积及严重指数(eczema area and severity index,EASI)评分[(2.70±1.74)分]、痊愈率(12.8%)及有效率(80.2%)与对照A组[(2.66±1.56)分、15.8%、88.2%]比较,差异无统计学意义,与对照B组[(5.51±2.96)分、3.8%、61.3%]比较,差异有统计学意义(P<0.05);②观察组不良反应发生率(7.0%)低于对照A组(18.4%)和对照B组(15.0%);③观察组复发率(13.2%)与对照B组(10.6%)比较,差异无统计学意义,但低于对照A组(26.9%),差异有统计学意义(P<0.05)。结论:序贯外用0.1%糠酸莫米松乳膏与0.03%他克莫司软膏治疗儿童特应性皮炎,临床疗效好,复发率低,安全性高,值得临床推广。
Objective:To study the clinical efficacy,safety and recurrence rate of childhood atopic dermatitis sequentially treated with topical 0.1%mometasone furoate cream and 0.03% tacrolimus ointment.Methods:A total of 270 cases of outpatients with childhood atopic dermatitis were divided into the treatment group(90 cases),control group A(90 cases)and control group B(90 cases).The treatment group received 0.1%mometasone furoate cream once a night for two weeks,followed 0.03%tacrolimus ointment twice-daily for additional two weeks,while control group A was treated with 0.1% mometasone furoate cream once a night,and control group B was treated with 0.03% tacrolimus ointment twice-daily for four weeks.Clinical efficacy and adverse reactions were evaluated at the end of the study,and the recurrence rate was assessed 4 weeks after the end of the treatment.Results:①The eczema area and severity index(EASI)score after treatment,cure rate,and total effective rate in the treatment group[(2.70±1.74)、12.8%、80.2%]were similar to that in control group A[(2.66±1.56)、15.8%、88.2%],but significantly different from that in the control group B[(5.51±2.96)、3.8%、61.3%];②The rate of adverse reactions was lower in the treatment group than in the controls(7.0%versus 18.4%and 15.0%).Moreover,the recurrence rate in the treatment group was comparable to that in the control group B(13.2% versus 10.6%),but lower than that in the control group A(26.9%).Conclusions:Sequential use of 0.1%mometasone furoate cream and 0.03% tacrolimus ointment is effective and safe for childhood atopic dermatitis,with lower recurrence rate.It is worth to try.
作者
卢静静
郑源泉
王攀
柯欢
付桂莉
LU Jing-jing;ZHENG Yuan-quan;WANG Pan;KE Huan;FU Gui-li(Department of Dermatology,Wuhan Children’s Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430016,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2019年第11期695-697,共3页
Journal of Clinical Dermatology
关键词
特应性皮炎
糠酸莫米松
他克莫司
atopic dermatitis
mometasone furoate cream
tacrolimus ointment
