摘要
目的:探讨血清内皮细胞特异性分子-1(ESM-1)和单核细胞趋化蛋白-1(MCP-1)在卒中后癫痫(PSE)患者中的表达水平,并分析其与患者不同临床特征的关系。方法:选择2019年1月至2020年7月山东第一医科大学附属莱钢医院收治的310例脑卒中患者作为研究对象,根据卒中后1个月内是否发作癫痫将患者分为癫痫组(PSE组,n=56)和非癫痫组(非PSE组,n=254)。应用ELISA技术测定所有研究对象血清中ESM-1、MCP-1的水平。结果:两组患者血清中ESM-1、MCP-1的水平差异有统计学意义(P<0.05)。PSE组血清ESM-1、MCP-1水平与癫痫发生时间、癫痫发作类型及癫痫控制情况有关,与卒中类型及癫痫灶部位无关。Spearman相关分析显示,PSE组血清ESM-1与MCP-1的表达呈正相关。Logistic回归分析显示,脑出血、皮层病灶、血清ESM-1和MCP-1水平高均是PSE发生的独立危险因素(P<0.05)。ROC曲线分析显示,血清ESM-1联合MCP-1水平预测PSE发生的曲线下面积(AUC)高于两者单独检测诊断,敏感度和特异度分别为92.64%和83.75%。结论:血清ESM-1、MCP-1参与免疫炎症,是PSE发生的独立危险因素,可能是预测PSE发生的有效血清学指标。
Objective:To investigate the expressions of ESM-1 and MCP-1 in serum of patients with post stroke epilepsy(PSE),and to analyze the relationship between two indicators and clinical features of patients.Methods:Total 310 stroke patients admitted to Laigang Hospital Affiliated to Shandong First Medical University from January 2019 to July 2020 were selected as research objects.According to whether secondary epilepsy occurred within one month after stroke,they were divided into PSE group(56 cases)and post stroke non epilepsy group(254 cases).ELISA was used to determine serum ESM-1 and MCP-1 levels.Results:The levels of serum ESM-1 and MCP-1 were different between the two groups(P<0.05).The levels of serum ESM-1 and MCP-1 in PSE group were associated with time,type and control of epilepsy,while they had nothing with the stroke type and the focus site.Spearman analysis showed that serum ESM-1 level was positively correlated with MCP-1 level in patients with PSE.Logistic regression showed that cerebral hemorrhage,the cortical lesion and the high levels of serum ESM-1 and MCP-1 were independent risk factors for PSE(P<0.05).ROC curve analysis showed that the area undercurve(AUC)of serum ESM-1 combined with MCP-1 level in predicting the occurrence of was higher than that of the two diagnostic methods alone,and the prediction sensitivity and specificity were 92.64%and 83.75%respectively.Conclusion:The serum ESM-1 and MCP-1 involved in immune inflammation,and they are independent risk factors for the occurrence of PSE,and which might be effective serum markers for evaluating the occurrence of PSE.
作者
王丽香
于振江
李强
贾文歆
程娜
WANG Lixiang;YU Zhenjiang;LI Qiang;JIA Wenxin;CHENG Na(Department of Neurology,Laigang Hospital Affiliated to Shandong First Medical University,Jinan 271100,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2022年第23期2912-2915,共4页
Chinese Journal of Immunology
基金
2021年济南市卫生健康委员会科技计划项目(2021-1-22)。
