摘要
糖尿病肾病(diabetic nephropathy,DN)是一项全球的公共健康问题,具有高发病率,增加患者死亡风险的特点。目前DN发病机制尚未被阐明,也无有效的治疗方式阻止疾病向终末期肾病进展。外泌体既往被认为是一种生物“废料”,但近年来研究表明:外泌体介导细胞之间的信息交流及物质传递,在正常状态及疾病病理生理过程中发挥重要作用。在DN相关研究中,肾固有细胞来源外泌体主要参与炎症反应、纤维化的发生和发展;间充质干细胞来源外泌体可通过调节细胞凋亡、增殖、免疫应答发挥肾保护作用;尿液外泌体非编码RNA及蛋白质有望成为DN诊断及预测疾病进展的新型生物标志物。全面理解外泌体在DN中的生物学作用,有利于推动相关临床转化实验发展,开发新的治疗策略。
Diabetic nephropathy(DN) is a global public health problem with high morbidity and increased risk of death. Its specific pathogenesis has not been clarified at present, and there is no effective treatment to prevent the disease from progressing to end-stage renal disease. Exosomes were previously considered as a kind of biological “waste”, but in recent years, studies have shown that exosomes mediate information exchange and material transfer between cells, and play an important role in normal state and disease pathophysiology. In DN-related research, renal intrinsic cell-derived exosomes are mainly involved in the occurrence and development of inflammatory response and fibrosis;mesenchymal stem cell-derived exosomes could play a renal protective role by regulating cell apoptosis, proliferation and immune response;urinary exosomal non-coding RNAs and proteins are expected to become novel biomarkers for the diagnosis and prediction of disease progression in DN. A comprehensive understanding of the biological role of exosomes in DN is conducive to promoting the development of relevant clinical translational experiments and developing new therapeutic strategies.
作者
王秀芬(综述)
肖湘成
唐文彬(审校)
WANG Xiufen;XIAO Xiangcheng;TANG Wenbin(Department of Nephrology,Xiangya Hospital,Central South University,Changsha 410008;Health Management Center,Xiangya Hospital,Central South University,Changsha 410008,China)
出处
《临床与病理杂志》
CAS
2022年第12期3117-3125,共9页
Journal of Clinical and Pathological Research
基金
国家重点研发计划(2020YFC2005000)
湖南省自然科学基金(2020JJ5921)。
