摘要
目的探讨广泛期小细胞肺癌(SCLC)患者一线化疗2周期前后血清胃泌素释放肽前体(ProGRP)水平变化率对疗效的预测价值。方法收集2016年4月1日至2021年6月30日在浙江省人民医院治疗的广泛期SCLC患者68例,经2周期化疗后评估患者疗效,根据疗效将患者分为疾病控制(DC)组和疾病进展(PD)组。运用广义线性模型和线性趋势检验评价化疗前后ProGRP水平变化率与化疗疗效的关系,采用ROC曲线评估血清ProGRP水平变化率预测患者化疗疗效的效能。结果2周期化疗后DC组57例,PD组11例。广义线性模型和线性趋势检验均显示ProGRP水平变化率与广泛期SCLC患者化疗疗效PD呈正相关(均P<0.01)。ProGRP水平变化率预测化疗疗效的AUC为0.925(P<0.01),ProGRP水平变化率最佳阈值为18.07%,灵敏度为0.818,特异度为0.983。结论广泛期SCLC患者一线化疗2周期前后ProGRP水平变化率可以有效预测化疗疗效,可作为影像学评价的重要辅助工具。
Objective To investigate the value of change rates in serum ProGRP levels for predicting efficacy of firstline chemotherapy in patients with extensive-stage small cell lung cancer(SCLC).Methods Clinical data of 68 patients with extensive-stage SCLC who received first-line chemotherapy in Zhejiang Provincial People’s Hospital from April 2016 to June2021 were retrospectively analyzed.Serum ProGRP levels were measured pre-and post-two cycles of chemotherapy and the efficacy of the patients was evaluated after the second cycle.According to the efficacy,the patients were divided into disease control(DC)group and progressive disease(PD)group.The generalized linear model(GLM)and linear trend test were used to evaluate the relationship between the change rates of ProGRP levels and the efficacy of chemotherapy.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of change rates of ProGRP level for efficacy of chemotherapy.Results After the second chemotherapeutic cycle,there were 57 patients in the DC group and 11patients in the PD group.The GLM and linear trend test showed that the change rates of ProGRP level were positively correlated with PD in patients with extensive-stage SCLC(P<0.01).The area under ROC curve(AUC)of ProGRP level change rates in predicting chemotherapy efficacy was 0.925(P<0.01);with an optimal cut-off value of 18.07%,the sensitivity and specificity were 0.818 and 0.983,respectively.Conclusion In patients with extensive-stage SCLC,the change rates of ProGRP levels pre-and post-two cycles of first-line chemotherapy can effectively predict the efficacy of chemotherapy.
作者
孙洁
钦志泉
卢丽琴
胡晓
周红英
朱秀明
洪誉鹏
李晓艺
杨胡娟
赵同伟
SUN Jie;QIN Zhiquan;LU Liqin;HU Xiao;ZHOU Hongying;ZHU Xiuming;HONG Yupeng;LI Xiaoyi;YANG Hujuan;ZHAO Tongwei(Graduate School of Clinical Medicine,Bengbu Medical College,Bengbu 233030,China;不详)
出处
《浙江医学》
CAS
2023年第1期28-32,共5页
Zhejiang Medical Journal
基金
浙江省医药卫生科技计划项目(2019KY274)
浙江省中医药科技计划项目(2018ZB014)。
关键词
小细胞肺癌
胃泌素释放肽前体
化疗
疗效
Small cell lung cancer
Progastrin-releasing peptide
Chemotherapy
Efficacy
