摘要
目的探讨双抗、蛭龙活血通瘀胶囊、头体针联用治疗短暂性脑缺血发作(Transient ischemic attack,TIA)的疗效及对早期卒中的预防效果。方法选取2019年1月—2021年11月期间西南医科大学附属中医医院收治的TIA患者110例,按治疗方法的不同分为对照1组36例、对照2组36例、治疗组38例。对照1组应用双抗治疗,对照2组在对照1组的基础上加服蛭龙活血通瘀胶囊,治疗组在对照2组的基础上加用头体针治疗。治疗2周后,观察比较3组患者临床疗效、ABCD2评分,治疗前后血液流变学、经颅多普勒检测[基底动脉(Basilar artery,BA)、椎动脉(Vertebral artery,VA)、大脑中动脉(Middle cerebral artery,MCA)的峰流速(Peak velocity,Vm)与血管搏动指数(Pulsatility index,PI)]。结果治疗后3组患者血浆黏度、高切黏度、低切黏度指标均较治疗前降低,差异有统计学意义(P<0.05);且对照2组血浆黏度、高切黏度、低切黏度指标均较对照1组明显降低,治疗组血浆黏度、高切黏度、低切黏度指标均较对照2组明显降低,差异有统计学意义(P<0.05)。治疗后3组患者BA、MCA的Vm指数均高于治疗前,BA、VA、MCA的PI指数均低于治疗前,差异有统计学意义(P<`0.05);且对照2组BA、MCA的Vm指数均高于对照1组,BA、VA、MCA的PI指数均低于对照1组,治疗组BA、MCA的Vm指数均高于对照2组,BA、VA、MCA的PI指数均低于对照2组,差异有统计学意义(P<`0.05)。治疗后3组患者ABCD2评分均低于治疗前,差异有统计学意义(P<`0.05);且对照2组、治疗组均低于对照1组,治疗组低于对照2组,差异有统计学意义(P<0.05)。治疗后治疗组总有效率为97.14%(34/35),对照2组总有效率为94.29%(33/35),对照1组总有效率为82.35%(28/34),治疗组与对照1组比较,差异有统计学意义(P<`0.05)。结论相较于单纯的药物治疗,TIA患者联合应用双抗、蛭龙活血通瘀胶囊合头体针治疗的效果更为显著,并对早期卒中的发生�
Objective To explore the efficacy of the combination of dual antiplatelet therapy,Zhilong Huoxue Tongyu Capsules,and head-body acupuncture in the treatment of transient ischemic attack(TIA)and its preventive effect on early stroke.Methods A total of 110 patients with TIA admitted to the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University from January 2019 to November 2021 were selected and divided into a control 1 group(n=36),a control 2 group(n=36),and a treatment group(n=38)according to different treatment methods.The patients in the control 1 and 2 groups underwent dual antiplatelet therapy,while those in the control 2 group received additional Zhilong Huoxue Tongyu Capsules.The patients in the treatment group were treated with a combination of dual antiplatelet therapy,Zhilong Huoxue Tongyu Capsules,and head-body acupuncture.After two weeks of treatment,the clinical efficacy,ABCD2 score,blood rheology,and transcranial Doppler measurements[peak velocity(Vm)and pulsatility index(PI)of basilar artery(BA),vertebral artery(VA),and middle cerebral artery(MCA)]before and after treatment were observed and compared among the three groups.Results After treatment,plasma viscosity,high-cut viscosity,and low-cut viscosity of patients in the three groups were lower than those before treatment(P<0.05).In terms of the above three indexes,the control 2 group was lower than the control 1 group,and the treatment group was lower than the control 2 group(P<0.05).After treatment,the Vm of BA and MCA in all three groups was higher than that before treatment,and the PI of BA,VA,and MCA was lower than that before treatment(P<0.05).In terms of the Vm of BA and MCA,the control 2 group was higher than the control 1 group,and the treatment group was higher than the control 2 group(P<0.05).In terms of the PI of BA,VA,and MCA,the control 2 group was lower than the control 1 group,and the treatment group was lower than the control 2 group(P<0.05).After treatment,the ABCD2 scores of patients in all three groups w
作者
叶丽莎
张德绸
白雪
唐红梅
YE Li-sha;ZHANG De-chou;BAI Xue;TANG Hong-mei(Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou Sichuan 646000)
出处
《世界中西医结合杂志》
2022年第12期2435-2439,共5页
World Journal of Integrated Traditional and Western Medicine
基金
2018年第一批省级科技计划项目(2018SZ0060)。
关键词
短暂性脑缺血发作
早期卒中
双抗
蛭龙活血通瘀胶囊
头体针
Transient Ischemic Attack
Early Stroke
Dual Antiplatelet Therapy
Zhilong Huoxue Tongyu Capsules
Head-Body Acupuncture
