摘要
目的:探讨无痛分娩对妊娠期高血压疾病(HDCP)产妇围产期血清炎症因子和血流动力学的影响。方法:选取2018年1月-2021年3月在本院分娩的HDCP产妇120例,其中常规分娩60例(常规组),无痛分娩60例(无痛组);同期行无痛分娩的60例健康孕妇为对照组。检测各组产妇镇痛前(T1)、宫口全开(T2)、胎儿娩出(T3)、胎儿娩出24h(T4)时血清炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平和血流动力学指标心率(HR)、平均动脉压(MAP)、心输出量(CO)。结果:无痛组与常规组第一产程、第二产程、第三产程、初乳时间无差异但均低于常规组,新生儿1min Apgar无差异但均高于常规组(均P<0.05),3组新生儿5min Apgar评分无差异(P>0.05)。各组T1时血清IL-6、TNF-α水平无差异(P>0.05);T2、T3、T4时无痛组和对照组血清IL-6、TNF-α水平无差异但均低于常规组(P<0.05);血流动力学指标HR、MAP、CO,T1、T4时3组无差异(P>0.05),T2、T3时无痛组和对照组均低于常规组(P<0.05)。结论:无痛分娩可有效降低HDCP孕妇围产期血清炎症因子水平,且对血流动力学的影响较小,对HDCP孕妇合理实施无痛分娩安全有效。
Objective:To investigate the effects of painless labor of pregnant women with hypertensive disorder complicating pregnancy(HDCP)on their serum inflammatory factors and hemodynamics.Methods:A total of 120 women with HDCP who had given birth in hospital were selected from January 2018 to March 2021,which included 60 cases with routine delivery in group A and 60 cases with painless delivery in group B.Another 60 healthy pregnant women who underwent painless labor were selected in group C during the same period.The levels of serum inflammatory cytokines,such as interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and hemodynamic indicators,such as heart rate(HR),mean arterial pressure(MAP),and cardiac output(CO)of the women in the three groups before analgesia(T1),full opening of the uterine orifice(T2),fetal delivery(T3),and 24h of fetal delivery(T4)were detected.Results:The first stage of labor time,the second stage of labor time,the third stage of labor time,and the time the colostrum feeding of the women in group B and group A showed no significant different,but which of the women in group B and group A were all significantly lower than those of the women in group C.The 1min Apgar of newborns in group B and group A showed no significant different,but which of the newborns in group B and group A were all significantly higher than those of the newborns in group A(all P<0.05).There was no significant difference in 5min Apgar score of the newborns among the three groups(P>0.05).There were no significant differences in the levels of serum IL-6 and TNF-αof the women at T1 among the three groups(P>0.05).The levels of serum IL-6 and TNF-αof the women in group B and group C at T2,T3 and T4 showed no significantly different,but which of the women in group B and group C were significantly lower than those of the women in group A(P<0.05).There were no significant differences in the values of hemodynamic indexes,such as HR,MAP,CO,of the women at T1and T4among the three groups(P>0.05),but the values of hemodynamic indexes of
作者
秦牧
张世彬
党彩玲
QIN Mu;ZHANG Shibin;DANG Cailing(The Second People’s Hospital of Yibin,Yibin,Sichuan Province,644000)
出处
《中国计划生育学杂志》
2023年第1期80-84,共5页
Chinese Journal of Family Planning
关键词
无痛分娩
妊娠期高血压疾病
炎症因子
血流动力学
围产期
Painless delivery
Hypertensive disorder complicating pregnancy
Inflammatory factors
Hemodynamics
Perinatal period
