摘要
目的观察分析腰硬联合麻醉分娩镇痛对产妇血白细胞介素6(IL-6)、一氧化氮(NO)及T细胞亚群的影响。方法选取2014年6月至2015年7月期间收治的90例产妇,按照随机数表法将产妇分为观察组(n=45)和对照组(n=45)。观察组产妇采取腰硬联合麻醉分娩镇痛,对照组产妇进行自然分娩。比较两组镇痛疗效、IL-6、NO浓度变化、T细胞亚群水平变化和不良反应情况。结果分娩中,经治疗后,观察组总有效率为91.11%,高于对照组(75.56%),差异有统计学意义(P<0.05)。分娩前,两组产妇的IL-6及NO浓度差异无统计学意义(P>0.05);分娩后24 h,两组产妇IL-6及NO浓度均有升高,且观察组产妇IL-6及NO浓度低于对照组,差异有统计学意义(P<0.05)。分娩前,两组产妇的CD4^+、CD8^+及CD4^+/CD8^+水平差异无统计学意义(P>0.05);分娩后24 h,观察组产妇的CD4^+及CD4^+/CD8^+水平下降幅度小于对照组,观察组产妇CD8^+水平下降幅度大于对照组,差异有统计学意义(P<0.05)。分娩后,观察组不良反应总发生率(11.11%)低于对照组(51.11%),差异有统计学意义(P<0.05)。结论腰硬联合麻醉对产妇分娩镇痛疗效显著,可降低产妇IL-6及NO浓度,降低CD4^+、CD8^+、CD4^+/CD8^+水平,减少不良反应发生,安全性较高。
Objective To study influence of epidural anesthesia for labor analgesia on maternal serum IL-6,NO and T cell subsets.Methods 90 puerperants from June 2014 to July 2015 in our hospital were researched.They were divided randomly into observation and control groups.45 patients in the observation group,they were treated by CSEA labor analgesia.45 patients in the control group,using natural childbirth.The efficacy,IL-6,NO concentration change,T cell subsets levels,adverse reactions were compared.Results In parturition,total effective rate of the observation group（91.11%） higher than the control group（75.56%）,there were significant differences（P〈0.05）.There was no significant difference in IL-6 and NO concentration between the two groups before delivery（P〉0.05）.The levels of IL-6 and NO in the two groups were higher than those in the control group at 24 h after delivery,and the levels of IL-6 and NO in the observation group were significantly lower than those in the control group（P〈0.05）.Before parturition,their level of CD4^＋,CD8^＋and CD4^＋/CD8^＋had no significant difference between each other（P〉0.05）.24 hours after parturition,the level of CD4^＋,CD4^＋/CD8^＋of the observation group decreased faster than the control group,the level of CD8^＋of the control group decreased faster than the observation group,and there were significant differences（P〈0.05）.After parturition,the overall incidence of adverse reactions of the observation group（11.11%） lower than the control group（51.11%）,there were significant differences（P〈0.05）.Conclusion CSEA labor analgesia on maternal had significant effect,can effectively reduce IL-6 and NO concentration of maternal and effectively reduce CD4^＋,CD8^＋,CD4^＋/CD8^＋levels,reduce the incidence of adverse reactions and had highly security.
出处
《临床和实验医学杂志》
2017年第7期653-656,共4页
Journal of Clinical and Experimental Medicine
基金
湖北省卫生计生委员会科研项目(编号:WJ2015MB278)
