摘要
目的探讨甲苯磺酸瑞马唑仑用于老年患者无痛胃肠镜诊疗的安全性。方法选取2020年3月至2022年3月十堰市茅箭区人民医院接诊的100例行无痛胃肠镜的老年患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组50例。对照组采用丙泊酚复合舒芬太尼静脉麻醉,观察组采用甲苯磺酸瑞马唑仑复合舒芬太尼麻醉。比较两组患者的不良反应总发生率、不同时间点血流动力学指标及诱导时间、苏醒时间、离室时间。结果观察组的不良反应总发生率低于对组,差异有统计学意义(P<0.05)。给药前,两组患者的血氧饱和度(SpO_(2))、平均动脉压(MAP)、心率(HR)比较,差异无统计学意义(P>0.05)。肠镜操作即刻对照组的SpO_(2)、MAP、HR水平均低于给药前,差异有统计学意义(P<0.05),而观察组肠镜操作即刻与给药前比较,差异无统计学意义(P>0.05);观察组肠镜操作即刻的SpO_(2)、MAP、HR水平高于对照组,差异有统计学意义(P<0.05)。观察组的诱导时间、苏醒时间、离室时间短于对照组,差异有统计学意义(P<0.05)。结论甲苯磺酸瑞马唑仑用于老年患者无痛胃肠镜诊疗的安全性较高,有利于维持术中血流动力学稳定。
Objective To analyze the safety of Remazolam Tosylate for painless gastrointestinal endoscopy in elderly patients.Methods A total of 100 elderly patients receiving painless gastroenteroscopy from People's Hospital of Maojian District,Shiyan City from March 2020 to March 2022 were selected as research objects,they were divided into control group and observation group by random number table method,50 cases in each group.The control group was given intravenous anesthesia with Propofol combined with Sufentanil,while the observation group was given Remazolam Tosylate combined with Sufentanil anesthesia.The total incidence of adverse reactions,hemodynamics at different times,induction time,recovery time,and room separation time were compared between the two groups.Results The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before administration,there were no significant differences in blood oxygen saturation(SpO_(2)),mean arterial pressure(MAP)and heart rate(HR)between the two groups(P>0.05).The levels of SpO_(2),MAP and HR in the control group after immediate colonoscopy operation were lower than those before administration,with statistical significances(P<0.05),while there was no statistical significance in the observation group after immediate colonoscopy operation compared with those before administration(P>0.05).And the SpO_(2),MAP,and HR levels of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).The induction time,wake-up time,and exit time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Remazolam Tosylate is safe for painless gastrointestinal endoscopy diagnosis and treatment in elderly patients,and it is beneficial to maintain intraoperative hemodynamic stability.
作者
张健
ZHANG Jian(Department of Anesthesiology,People's Hospital of Maojian District,Shiyan City,Hubei Province,Shiyan 442012,China)
出处
《中国当代医药》
CAS
2023年第1期124-126,共3页
China Modern Medicine
