摘要
目的 探讨多模态MR(MRI平扫、DWI、DCE-MRI)在宫颈鳞癌同步放化疗(CCRT)疗效评估中的价值。方法 回顾性分析2018年9月—2020年12月在我院行CCRT的宫颈鳞癌患者61例,治疗前1周和治疗结束后1月均行盆腔MRI平扫、DWI、DCE-MRI扫描,测量CCRT前、后肿瘤最大径并按疗效将患者分为完全缓解(the complete remission,CR)组和部分缓解(the partial remission,PR)组,利用后处理工作站测量DCE-MRI和DWI定量参数:容量转移常数(Ktrans)、回流速率常数(Kep)、容积分数(Ve)、表观扩散系数(ADC)值,CCRT前、后各参数比较采用配对t检验;两组间CCRT前、后各参数的比较采用独立样本t检验。结果 宫颈鳞癌患者CCRT后Ktrans、Kep、Ve值较前减低,ADC值较前增高,差异具有统计学意义(P<0.01)。CCRT前CR组Ktrans、Kep值高于PR组、ADC值低于PR组,CCRT后CR组Ktrans、Ve值低于PR组,ADC值高于PR组,差异具有统计学意义(P<0.05)。结论 Ktrans和ADC值在一定程度上可以预测宫颈鳞癌CCRT早期疗效,有助于临床实施个体化精确治疗。
Objective To investigate the value of multimodal MR(MRI plain scan, diffusion weighted imaging(DWI),dynamic contrst enhanced magnetic resonace imaging(DCE-MRI)) on evaluating the treatment efficacy in patients with uterine cervical cancer under concurrent chemoradiotherapy(CCRT).Methods Sixty-one patients with advanced uterine cervical squamous cell carcinoma who underwent CCRT in our hospital from September 2018 to December 2020 were analyzed retrospectively, pelvic MRI plain scan, DWI and DCE-MRI scanning were performed one week before treatment and one month after treatment respectively.The maximum tumor diameter before and after CCRT were measured and patients were divided into the complete remission(CR) group and the partial remission(PR) group.Quantitative parameters of DCE-MRI and DWI,including Ktrans, Kep, Ve and ADC values, were measured by post-processing workstation.Paired t-test was used to compare parameters before and after CCRT.Independent sample t test was used to compare the parameters before and after CCRT between the two groups.Results Ktrans, Kep, Ve showed significant decrease(P<0.01),ADC value demonstrated significant increase(P<0.01) in patients with advanced uterine cervical squamous cell cancer after CCRT.Before CCRT,Ktrans and Kep values in CR group were higher than those in PR group, ADC values were lower than those in PR group, while after CCRT,Ktrans and Ve values in CR group were lower than those in PR group, and ADC values were higher than those in PR group, with statistical significance(P<0.05,P<0.01).Conclusion Ktrans and ADC values may help evaluate early changes of uterine cervical cancer to CCRT,and help precise individualized therapy in clinical practice.
作者
李伟兰
谢宗源
李晖
陈伟彬
张惠英
LI Weilan;XIE Zongyuan;LI Hui;CHEN Weibin;ZHANG Huiying(Department of Medical Imaging,Affiliated Hospital of North China University of Science and Technology,Tangshan 063000,China)
出处
《中国煤炭工业医学杂志》
2022年第5期506-509,共4页
Chinese Journal of Coal Industry Medicine
基金
河北省医学科学研究课题(编号:20201245)。
关键词
宫颈鳞癌
同步放化疗
MRI
动态对比增强
弥散加权成像
Uterine cervical squamous cell cancer
Concurrent chemoradiotherapy(CCRT)
Magnetic resonance imaging
Dynamic contrast-enhanced
Diffusion weighted imaging
