摘要
【目的】探讨辅助性T细胞22(Th22)及血清白细胞介素-22(IL-22)水平预测狼疮性肾炎(LN)患者病情程度的价值。【方法】三院收治的62例系统性红斑狼疮(SLE)患者,将肾活检切片肾小球>8个的患者纳入LN组(n=28),其余纳入SLE组(n=34),另选取同期体检健康者30例作为对照组。并将系统性红斑狼疮疾病活动指数(SLE-DAI)评分≥10分的LN患者设为活动组(n=11),<10分的LN患者为稳定组(n=17)。比较各组及不同病情LN患者的肾功能指标[血清尿素氮(BUN)、血清肌酐(Scr)、肾小球滤过率(GFR)]及辅助性T细胞1(Th1)、Th22、IL-22水平。分析Th22、IL-22水平预测LN患者病情程度的价值;以Spearman秩相关分析检验Th22、IL-22水平与LN患者SLE-DAI评分的相关性。【结果】对照组Scr、BUN、Th22、IL-22水平显著低于LN组和SLE组,GFR水平则高于LN组和SLE组(P<0.05);SLE组Scr、BUN水平显著低于LN组P<0.05);LN组和SLE组Th22、IL-22、GFR水平比较,差异均无统计学意义(P>0.05);三组间Th1水平比较,差异无统计学意义(P>0.05)。活动组与稳定组Scr、GFR、BUN、Th1水平比较,差异无统计学意义(P>0.05);活动组Th22、IL-22水平显著高于稳定组(P<0.05)。经受试者工作特征(ROC)曲线分析,Th22、IL-22水平预测LN患者病情程度的最佳截断值分别为Th22≥7.180%、IL-22≥64.955 pg/mL(均P<0.05)。相关性分析显示,Th22、IL-22水平与LN患者SLE-DAI评分均呈正相关(P<0.05)。【结论】SLE和LN患者外周血Th22、IL-22水平均显著高于正常人,且在不同病情程度LN患者中存在显著差异,其与LN患者疾病活动度呈显著正相关。
【Objective】To investigate the value of helper T cell 22(Th22)and serum interleukin-22(IL-22)levels in predicting the severity of lupus nephritis(LN).【Methods】Sixty two patients with systemic lupus erythematosus(SLE)were admitted to our hospital.The patients with more than 8 glomeruli in renal biopsy sections were included in the LN group(n=28),and the rest of patients were included in the SLE group(n=34).Meanwhile,30 healthy volunteers in the same period were selected as the control group.LN patients with SLE-DAI score≥10 were set as active group(n=11),and those with SLE-DAI score<10 were set as stable group(n=17).The renal function indexes(BUN,Scr,GFR)and the levels of helper T cell 1(Th1),Th22,IL-22 in each group were compared.The value of Th22 and IL-22 levels in predicting the severity of LN patients was analyzed.Spearman rank correlation analysis was used to reveal the correlation of levels of Th22 and IL-22 with SLE-DAI scores of LN patients.【Results】The levels of Scr,BUN,Th22,and IL-22 in the control group were significantly lower than those in the LN group and the SLE group,while the levels of GFR were higher than those in the two groups(P<0.05).The levels of Scr and BUN in the SLE group were significantly lower than those in the LN group(P<0.05).There was no significant difference in the levels of Th22,IL-22 and GFR between the LN group and the SLE group(P>0.05).There were no significant differences in Th1 levels among the three groups(P>0.05).There were no significant differences in the levels of SCR,GFR,BUN and Th1 between the active group and the stable group(P>0.05).Th22 and IL-22 levels in the active group were significantly higher than those in the stable group(P<0.05).According to ROC analysis,the best cutoff values of Th22 and IL-22 levels for predicting the severity of LN patients were Th22≥7.180%and IL-22≥64.955 pg/mL,respectively(both P<0.05).Correlation analysis showed that Th22 and IL-22 levels were positively correlated with SLE-DAI scores of LN patients(P<0.05).【Conclus
作者
高青青
杲和艳
赵成群
李晓龙
GAO Qing-qing;GAO He-yan;ZHAO Cheng-qun(Department of Nephrology,the First People's Hospital of Xianyang,Xianyang Shaanxi 712000)
出处
《医学临床研究》
CAS
2022年第12期1806-1809,共4页
Journal of Clinical Research
