摘要
目的分析胃癌患者血清血管生成素样蛋白5(ANGPTL5)及甲胎蛋白(AFP)的表达水平,并探讨二者与胃癌患者临床病理特征及预后的关系。方法选取2014年5月至2017年5月在承德医学院附属秦皇岛市第一医院接受治疗的胃癌患者52例为胃癌组;选取同时期在本院体检的健康者52名为对照组。检测两组血清ANGPTL5、AFP表达水平;采用Kaplan⁃Meier对胃癌患者3年的生存情况进行分析;采用COX法分析影响胃癌患者不良预后的危险因素。结果与对照组相比,胃癌组血清ANGPTL5、AFP表达水平较高,差异均有统计学意义(P<0.05)。ANGPTL5、AFP与胃癌患者临床分期、分化程度、淋巴结转移、浸润深度相关(P<0.05)。Kaplan⁃Meier法显示ANGPTL5、AFP低表达胃癌患者平均生存时间显著长于高表达患者,经Log Rank检验均具有统计学意义(x^(2)=8.002、8.074,P<0.05)。COX单因素及多因素分析显示,浸润深度HR为2.005(95%CI:1.624~2.476)、ANGPTL5高表达HR为2.427(95%CI:1.604~3.673)、AFP高表达HR为2.564(95%CI:1.724~3.812)是影响胃癌患者不良预后的独立危险因素(P均<0.05)。结论胃癌患者血清ANGPTL5、AFP表达水平呈升高趋势,与预后具有密切关系,可为临床诊治提供参考依据。
Objective To analyze the expression levels of serum angiopoietin like protein 5(ANGPTL5)and alpha fetoprotein(AFP)in patients with gastric cancer,and to explore their relationship with clinicopathological features and prognosis.Methods 52 patients with gastric cancer who were treated in Qinhuangdao First Hospital Affiliated to Chengde Medical College from May 2014 to May 2017 were selected as gastric cancer group;52 healthy people who received physical examination in our hospital during the same period were selected as the control group.The expression levels of serum ANGPTL5 and AFP in the two groups were detected.Kaplan Meier was used to analyze the 3⁃year survival of gastric cancer patients.Cox method was used to analyze the risk factors affecting the poor prognosis of gastric cancer patients.Results Compared with the control group,the expression levels of serum ANGPTL5 and AFP in gastric cancer group were higher,and the differences were statistically significant(P<0.05).ANGPTL5 and AFP were correlated with clinical stage,degree of differentiation,lymph node metastasis and depth of invasion(P<0.05).Kaplan Meier analysis showed that the average survival time of gastric cancer patients with low expression of ANGPTL5 and AFP was significantly longer than that of patients with high expression,which was statistically significant by log rank test(x^(2)=8.002,8.074,P<0.05).Cox univariate and multivariate analysis showed that HR of depth of invasion was 2.005(95%CI:1.624⁃2.476),HR of high expression of ANGPTL5 was 2.427(95%CI:1.604⁃3.673),HR of high expression of AFP was 2.564(95%CI:1.724⁃3.812)were independent risk factors for poor prognosis of gastric cancer patients(P<0.05).Conclusion The expression levels of serum ANGPTL5 and AFP in patients with gastric cancer showed an increasing trend,which is closely related to the prognosis,and can provide reference for clinical diagnosis and treatment.
作者
于佳瀚
高立明
孔梦悦
王昭慧
王超群
YU Jiahan;GAO Liming;KONG Mengyue;WANG Zhaohui;WANG Chaoqun(Department of Oncology,Qinhuangdao First Hospital Affiliated to Chengde Medical College,Qinhuangdao,Hebei,China,066000)
出处
《分子诊断与治疗杂志》
2022年第12期2171-2174,2179,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省科技计划资助项目(182777164)。
关键词
胃癌
血管生成素样蛋白5
甲胎蛋白
预后
Gastric cancer
Angiopoietin like protein 5
Alpha⁃fetoprotein
prognosis
