摘要
目的:探讨重复经颅磁刺激(rTMS)联合氯氮平治疗难治性精神分裂症(SCH)的疗效。方法:将医院收治的84例难治性SCH患者按随机分配原则分为两组,各42例。研究组以rTMS联合氯氮平治疗,对照组仅以氯氮平治疗,比较两组治疗效果。结果:治疗后,研究组患者PANSS评分低于对照组,Hcy水平低于对照组,MMSE评分高于对照组,治疗总有效率优于对照组(均P<0.05);两组患者治疗前后血清IL-10水平及不良反应差异均无统计学意义(P>0.05)。结论:针对难治性SCH以rTMS联合氯氮平治疗疗效确切,可改善临床症状,提升认知功能,降低同型半胱氨酸水平,安全性高。
Objective:To observe the efficacy of repeated transcranial magnetic stimulation(rTMS)combined with clozapine in the treatment of refractory schizophrenia(SCH).Methods:84 patients with refractory SCH admitted to hospital were randomly divided into two groups with 42 in each.The study group was treated with rTMS combined with clozapine,while the control group was only treated with clozapine.The therapeutic effects of the two groups were compared.Results:After treatment,PANSS score,Hcy level,MMSE score in the study group were lower than those in the control group,and the total effective rate was better than those in the control group(all P<0.05);There was no significant difference in serum IL-10 level and adverse reactions between the two groups before and after treatment(P>0.05).Conclusion:RTMS combined with clozapine has a definite therapeutic effect on refractory SCH,which can improve clinical symptoms,enhance cognitive function,reduce homocysteine level,and has high safety.
作者
植丽冰
冼彩华
陈狄龙
ZHI Li-bing;XIAN Cai-hua;CHEN Di-long(Guangdong Zhaoqing Retired Military Hospital,Zhaoqing 526070,Guangdong)
出处
《安徽医专学报》
2022年第6期31-33,共3页
Journal of Anhui Medical College
基金
肇庆市科技计划项目(编号:2021040314049)。
