摘要
人类肠道中含有一个高度复杂的微生物群落,称为肠道微生物群。肠道微生物失衡在多种疾病的发病机制中发挥重要作用,宿主免疫系统与肠道微生物群间的相互作用正引起越来越多的关注。核苷酸结合寡聚化结构域样受体(NLRs)包括大量天然免疫传感器和受体,是病原体识别、宿主免疫和炎症的核心调节因子,在人类疾病中至关重要。本文主要阐述NLRs在调控微生物群落中的潜在作用,并讨论肠道微生物与NLRs相互连接的功能轴如何影响结肠炎、炎症性肠病和结直肠癌的调节。
Gastrointestinal tract harbors a highly complex microbial community,which is referred to as gut microbiota.With increasing evidence suggesting that the imbalance of gut microbiota plays a significant role in pathogenesis of multiple diseases,interactions between host immune system and gut microbiota are now attracting emerging interest.Nucleotide-binding and leucine-rich repeat-containing receptors(NLRs)encompass a large number of innate immune sensors and receptors,and several family members are central regulators of pathogen recognition,host immunity and inflammation with utmost importance in human diseases.In this review,we focus on the potential roles played by NLRs in controlling and shaping the microbiota community and discuss how the functional axes interconnecting gut microbiota with NLRs impact the modulation of colitis,inflammatory bowel diseases and colorectal cancer.
作者
顾亚琴
陈磊
吴红雁
GU Yaqin;CHEN Lei;WU Hongyan(Jiangsu Vocational College of Medicine,Yancheng 210042,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2022年第19期2414-2419,共6页
Chinese Journal of Immunology
基金
国家自然科学基金面上项目(81873134)。
关键词
肠道微生物
NLR蛋白
肠道稳态
Gut microbiota
NLR proteins
Intestinal homeostasis
