摘要
核苷酸结合寡聚化结构域样受体(nucleotide-binding oligomerization domain like receptors,NLRs)在机体的固有免疫和适应性免疫过程中均发挥着独特的调控作用,其成员不仅可作为适配器介导NF-κB通路、MAPK通路及I型IFN信号通路,又可作为调节器与信号通路关键蛋白互作,继而通过细胞凋亡和细胞自噬等方式调控细胞免疫应答反应,维持宿主细胞内环境的稳态。鉴于近年来NLRs在机体免疫防御及肿瘤发生中的作用备受关注,该文就NLRs在抗感染免疫及肿瘤免疫过程中的调控作用进行简要论述,以期为由病原微生物引起的疾病及癌症的治疗提供新思路。
NLRs(nucleotide-binding oligomerization domain like receptors)play a unique regulatory role in the innate immunity and adaptive immunity.Its members not only act as adapters to mediate the NF-κB pathway,MAPK pathway and type I IFN signaling pathway,but also act as regulators to interact with key moleculars in the signaling pathways.Then,they regulate the cellular immune response through apoptosis and autophagy to maintain the homeostasis of host cells.In recent years,the roles of NLRs in the immune defense and tumorigenesis have attracted much attention.In this paper,the regulatory roles of NLRs in the process of anti-infective immunity and tumor immunity are briefly discussed in order to provide new ideas for the treatment of diseases and cancers caused by pathogenic microorganisms.
作者
马瑞仙
李向茸
冯若飞
MA Ruixian;LI Xiangrong;FENG Ruofei(Key Laboratory of Biotechnology&Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730030,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第11期2019-2028,共10页
Chinese Journal of Cell Biology
基金
西北民族大学中央高校基本科研业务费资金项目(批准号:31920200003、31920190003)
西北民族大学“双一流”和特色发展引导专项–生物工程特色学科(批准号:10018703[2017]、1001070204[2018]、11080306[2019])资助的课题
国家民委中青年英才计划(批准号:[2018]98)
教育部创新团队项目(批准号:IRT_17R88)。
