摘要
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures,resulting in the release of cellular contents that can activate strong inflammatory and immune responses.Pyroptosis,an innate immune response,can be triggered by the activation of inflammasomes by various influencing factors.Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11,both of which cleave gasdermin D to release its N-terminal domain,which can bind membrane lipids and perforate the cell membrane.Here,we review the latest advancements in research on the mechanisms of pyroptosis,newly discovered influencing factors,antitumoral properties,and applications in various diseases.Moreover,this review also provides updates on potential targeted therapies for inflammation and cancers,methods for clinical prevention,and finally challenges and future directions in the field.
基金
This work was supported by a special program from the National Key Research and Development Program of China(2021YFA1101000 to LZ)
the Chinese National Natural Science Funds(U20A201376,U20A20393,and 31925013 to LZ,82041009,31871405,and 32125016 to FZ,92169122 and 31701232 to FX,32025011 to FW,31822031,31970664,31961160725 to JH and TL)
the Science and Technology Plan Project of Suzhou(SYS2019020 to FX)
the Jiangsu National Science Foundation(BK20180043 to FZ)
Natural Science Foundation of Zhejiang Province(LZ19C070001 to FW)
the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003 to FZ).
