摘要
目的 观察中药浸泡口腔预防脑血管意外患者吸入性肺炎效果。方法 纳入金华市人民医院收治的82例脑血管意外患者(2019年6月-2022年1月)82例,根据随机数字表法将纳入的患者平均分为对照组(41例)与观察组(41例),给予对照组患者复方氯已定含漱液(口泰)治疗,给予观察组患者中药浸泡口腔治疗。比较两组患者吸入性肺炎发生率、临床疗效、治疗前后患者口腔细菌菌落计数变化、中国卒中量表评分(CSS)及美国国立卫生研究院卒中量表(NIHSS)、Barthel指数(BI)评分变化、超敏C反应蛋白(hs-CRP)水平及白细胞(WBC)计数变化、降钙素原(PCT)水平变化、不良反应,治疗前后进行痰培养,比较两组患者多药耐药性发生率。结果 与对照组(29.27%,12/41)相比,观察组患者吸入性肺炎发生率(9.76%,4/41)更低(P<0.05);观察组患者治愈率(73.17%,30/41)比对照组患者(41.46%,17/41)高(P<0.05);治疗前,两组患者口腔细菌菌落计数、CSS评分、NIHSS评分、BI评分、hs-CRP及WBC、PCT水平等指标比较(P>0.05),治疗后各组患者口腔细菌菌落计数减少,CSS评分、NIHSS评分、BI评分均改善,hs-CRP及WBC、PCT水平下降,观察组患者治疗后口腔细菌菌落计数、CSS评分、NIHSS评分、BI评分、hs-CRP及WBC、PCT水平等指标均优于对照组(P<0.05);观察组发生1例乏力,对照组1例腹胀,不良反应均较少(P>0.05);治疗后各组患者多药耐药性发生率均降低,观察组比对照组更低(P<0.05)。结论 中药浸泡口腔预防脑血管意外患者吸入性肺炎效果良好,可显著降低患者吸入性肺炎发生率,一定程度提升患者治愈率,降低患者多药耐药性发生率,利于患者康复,且不良反应少,安全可靠。
Objective To observe the effect of oral cavity soaked with traditional Chinese medicine on prevention of inhalation pneumonia in patients with cerebrovascular accident.Methods Eighty-two patients with cerebrovascular accident(June 2019—January 2022)in this study, according to random number table method were divided into control group(41 cases)and observation group(41 cases).The patients in the control group were treated with compound chlorhexidine gargle(Koutai)and those in the observation were treated with oral cavity soaked with traditional Chinese medicine for oral treatment.Data observation: The incidence of aspiration pneumonia, clinical efficacy, changes in oral bacterial colony count, Chinese Stroke Scale score(CSS),National Institutes of Health Stroke Scale(NIHSS),Barthel index(BI)score, high sensitivity C-reactive protein(hs-CRP)level and white blood cell count(WBC),the changes in procalcitonin(PCT)level and adverse reactions were compared between two groups.The sputum culture was performed before and after treatment, and the incidence of multidrug resistance was compared between the two groups.Results Compared with 29.27%(12/41) in the control group, the incidence of aspiration pneumonia in the observation group was lower(9.76%,4/41)(P<0.05).The cure rate of the observation group(73.17%,30/41)was higher than that of the control group(41.46%,17/41)(P<0.05).Before treatment, the oral bacterial colony count, CSS score, NIHSS score, BI score, the levels of hs-CRP,WBC and PCT and other indicators of two groups were not significant(P>0.05).After treatment, the oral bacterial colony count of two groups was decreased, while CSS score, NIHSS score and BI score were improved.The levels of hs-CRP,WBC and PCT decreased, and oral bacterial colony count, CSS score, NIHSS score, BI score, levels of hS-CRP,WBC and PCT in the observation group were better than those in the control group after treatment(P<0.05).There was 1 case of fatigue in the observation group and 1 case of abdominal distension in the control group.
作者
陈可
张威
黄逸勋
CHEN Ke;ZHANG Wei;HUANG Yixun(Intensive Care Unit of Jinhua People's Hospital,Jinhua 321015,Zhejiang,China)
出处
《辽宁中医杂志》
CAS
2022年第12期92-95,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
浙江省医药卫生科技计划项目(2019KY619)。
关键词
脑血管意外
中药浸泡口腔
复方氯已定含漱液
吸入性肺炎
疗效
不良反应
cerebrovascular accident
oral cavity soaked with traditional Chinese medicine
compound chlorhexidine gargle
aspiration pneumonia
curative effect
adverse reactions
