摘要
背景现阶段我国老年急性脑梗死发病率较高,多数患者伴有瘫痪、失语等后遗症,进而增加了后期恢复难度。若患者救治方法及管理不当,则易丧失日常生活能力,严重影响患者的生活质量,因此科学、有效的治疗及管理对急性脑梗死患者尤为重要。目的探讨卒中单元管理联合重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗急性脑梗死的临床疗效及安全性。方法选取巴彦淖尔市医院2019年收治的急性脑梗死患者114例,根据随机数字法分为对照组和观察组,各57例。患者入院后均给予rt-PA静脉溶栓治疗,在此基础上,对照组患者采用常规护理,观察组患者采用卒中单元管理,两组患者均持续干预21 d。比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表、Barthel指数评定量表(BI)评分及血尿酸水平,并比较两组患者临床疗效及并发症发生率。结果观察组患者治疗后NIHSS评分、改良Rankin量表评分及血尿酸水平低于对照组,BI评分高于对照组(P<0.05)。观察组患者临床疗效优于对照组(P<0.05)。两组患者治疗期间并发症发生率比较,差异无统计学意义(P>0.05)。结论卒中单元管理联合rt-PA静脉溶栓治疗急性脑梗死的临床疗效确切,可有效改善患者的神经功能及日常生活能力,降低血尿酸水平,且安全性高。
Background At present,incidence of acute cerebral infarction in elderly patients is gradually increasing in China,since most of patients are accompanied with paralysis,aphasia and other sequelae after treatment,it is difficult to recover later.In addition,if the patients are not treated properly,they will lose the ability of daily living,which seriously affects the quality of life.Therefore,it is particularly important for such patients to choose scientific and effective treatment and management.Objective To observe the clinical effect and safety of stroke unit management combined with recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis in the treatment of acute cerebral infarction.Methods 114 patients with acute cerebral infarction who were admitted to Bayannur Hospital from 2019 were selected,and they were divided into control group and observation group according random number table method,57 cases in each group.All patients were given rt-PA intravenous thrombolysis,on the basis of that,patients in control group were given routine nursing,patients in observation group were given stroke unit management.Both groups were intervented for 21 days.Scores of National Institutes of Health Stroke Scale(NIHSS),modified Rankin Scale(mRs),Barthel Index Rating Scale(BI)and serum uric acid level were compared between the two groups before and after treatment,as well as clinical effect and incidence of complication.Results Scores of NIHSS,mRs and serum uric acid level in observation group were lower than those in control group,BI score in observation group was higher than that in control group(P<0.05).Clinical effect in observation group was better than that in control group(P<0.05).There was no significant difference in incidence of complications between the two groups(P>0.05).Conclusion Stroke unit management combined with rt-PA intravenous thrombolysis have an exact clinical effect in patients with acute cerebral infarction,which can improve nerve function and ability of daily life,reduce serum uric ac
作者
范鸿飞
孙雅丽
FAN Hongfei;SUN Yali(Department of Neurology,Bayannur Hospital,Bayannur 015000,China)
出处
《实用心脑肺血管病杂志》
2021年第1期109-113,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
卒中单元
重组组织型纤溶酶原激活剂
静脉溶栓
尿酸
治疗结果
Brain infarction
Stroke unit
Recombinant tissue plasminogen activator
Intravenous thrombolysis
Uric acid
Treatment outcome
