摘要
现今,肿瘤标记物检测在肺腺癌诊断中发挥了重要作用,在肺腺癌侵袭、扩散或转移的情况下,肿瘤标记物仍显示出高效的提示功能,但也存在一定局限性。骨作为肺腺癌最易转移的部位之一,在被肺腺癌侵袭前后肿瘤标志物的水平变化与肿瘤标志物在肿瘤骨转移中的作用更值得探究。传统肺腺癌相关肿瘤标记物包括表皮生长因子受体(EGFR)、癌胚抗原(CEA)、血清糖类抗原125(CA125)等。近年来,肿瘤标志物与癌症之间的联系逐渐被发现,其联合影像学检查展示出良好的前景。为临床对癌症的诊断、治疗及检测提供了巨大帮助。本文对肿瘤标志物的最新研究进展及对肺腺癌骨转移的作用作一综述,以期为临床上肺腺癌骨转移诊断与治疗提供参考。
Nowadays,tumor marker detection plays an important role in the diagnosis of lung adenocarcinoma.In the case of invasion,diffusion or metastasis of lung adenocarcinoma,tumor markers still show efficient prompt function,but there are also some limitations.Bone is one of the most metastatic sites of lung adenocarcinoma.The changes of tumor markers before and after invasion of lung adenocarcinoma and the role of tumor markers in tumor bone metastasis are worth exploring.Traditional lung adenocarcinoma-related tumor markers include epidermal growth factor receptor(EGFR),carcinoembryonic antigen(CEA),serum carbohydrate antigen 125(CA125),etc.In recent years,the connection between tumor markers and cancer has been gradually discovered,and its combined imaging examination shows good prospects.It provides great help for clinical diagnosis,treatment and detection of cancer.This article reviews the latest research progress of tumor markers and their effects on bone metastasis of lung adenocarcinoma,in order to provide reference for clinical diagnosis and treatment of bone metastasis of lung adenocarcinoma.
作者
孔德伟
吴铭
张岩
KONG De-wei;WU Ming;ZHANG Yan(Postgraduate Training Base,Shanghai Pudong New Area Gongli Hospital,Ningxia Medical University,Shanghai 200120,China;Department of Orthopedics,Shanghai Pudong New Area Gongli Hospital,Shanghai 200120,China)
出处
《医学信息》
2022年第23期171-175,共5页
Journal of Medical Information
基金
国家自然科学基金面上项目(编号:81772383)
上海市浦东新区卫生系统领先人才培养计划(编号:PWRL2019-01)。
关键词
骨转移
肺腺癌
肺癌
肿瘤标志物
骨转换标记物
Bone metastasis
Lung adenocarcinoma
Lung cancer
Tumor markers
Bone conversion markers
