摘要
目的分析肺癌骨转移患者的临床病理特征及其与预后的关系。方法回顾性分析258例上海市肺科医院肺癌骨转移患者的病例资料,采用直接计算法计算其生存率,生存分析采用Kaplan-Meier法和Cox回归模型。结果肺腺癌骨转移发生率最高,骨转移好发部位依次是椎骨、骨盆和肋骨。全组患者的1年、2年生存率分别为52.3%、26.4%,中位生存期为12.6个月。生存分析显示,PS评分、骨转移数目、骨转移后是否化疗、血清AKP水平、血清CA242水平与预后相关(P<0.05),其他临床病理特征与预后均无关。Cox回归分析显示,临床分期、血清AKP水平、骨转移数目及PS评分为独立预后因素。结论初诊时临床分期、骨转移时血清AKP水平、骨转移数目及PS评分可能对肺癌预后影响较大。
Objective To analyze the clinical features and prognosis related factors of the bone metastasis of patients with lung cancer. Methods Clinical materials of 258 patients with bone metastases of lung cancer, who were treated in our hospital during Feb. 2006 to Feb. 2008, were retrospectively analyzed. 1- and 2-year survival rates were achieved by direct calculation method, univari- ate analysis was taken by Kaplan-Meier. Multivariate analysis were performed using Cox regression model. Results Incidence of bone metastases of adenoearcinoma was the highest and the predilection sites of bone metastases of lung cancer included spine, pelvis and fibs. One and two years survival rates were 52. 3% and 26. 4% ,respectively. The median survival time was 12. 6 months for lung cancer patients with bone metastases. On univariate analysis,the PS score, the number of bone lesions, chemotherapy after bone metastases, serum AKP and CA242 level were prognostic factors （ P 〈 0. 05 ）. On multivariate analysis using Cox regression method, clinical stage, serum AKP level, number of bone lesions and the PS score were independent prognostic factors. Conclusion Clinical stage of the first visit, serum AKP level,the number of bone lesions and the PS score have great influence on the prognosis of patients.
出处
《临床肿瘤学杂志》
CAS
2012年第5期433-436,共4页
Chinese Clinical Oncology
关键词
肺癌
骨转移
预后因素
Lung cancer
Bone metastasis
Prognostic factors
